Rare genetic diseases affecting skeletal development and oral health disparities among children and adolescents: a pathway analysis

International Dental Journal
Mario Vianna VettoreJanine Owens

Abstract

To examine the relationships of rare genetic diseases affecting skeletal development, socio-demographic characteristics, and oral health-related behaviours with dental clinical measures in children and adolescents. A cross-sectional study paired by age, gender and social class included 61 children and adolescents with osteogenesis imperfecta (n = 40) or mucopolysaccharidoses (n = 21) and those without genetic rare diseases (n = 60). Participants were selected at two referral hospitals for rare genetic diseases in the city of Belo Horizonte, Brazil. Caregivers completed a questionnaire to obtain age, gender, caregiver's schooling, social class, patterns of dental attendance and duration of breastfeeding. Oral hygiene, dental caries, dental anomalies and malocclusion were assessed through dental examinations. The relationships between variables were estimated through Pathway analysis using the maximum likelihood method. Rare genetic diseases affecting skeletal development were directly associated with dental caries (β = 0.22), dental anomalies (β = 0.36) and malocclusion (β = 0.29). They were also inversely linked to a preventive pattern of dental attendance (β = -0.25). Rare genetic diseases affecting skeletal development were a...Continue Reading

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Citations

Feb 11, 2021·International Journal of Environmental Research and Public Health·Gianmaria D'AddazioSergio Caputi
Jul 3, 2021·International Journal of Environmental Research and Public Health·Eitan MijiritskyMaayan Shacham

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