Rare Ginsenoside 20(R)-Rg3 Inhibits D-Galactose-Induced Liver and Kidney Injury by Regulating Oxidative Stress-Induced Apoptosis

The American Journal of Chinese Medicine
Wei LiZi Wang

Abstract

Oxidative stress is considered as a major factor in aging and exacerbates aging process through a variety of molecular mechanisms. D-galactose, a normal reducing sugar with high dose can cause the accumulation of reactive oxygen species (ROS) or stimulate free radical production indirectly by the formation of advanced glycation end products in tissues, finally resulting in oxidative stress. 20(R)-ginsenoside Rg3 (20(R)-Rg3), a major and representative component isolated from red ginseng (Panax ginseng C.A Meyer), has been shown to observably have an anti-oxidative effect. We thereby investigated the beneficial effects of 20(R)-Rg3 on D-galactose-induced oxidative stress injury and its underlying mechanisms. Our results showed that continuous injection of D-galactose with 800[Formula: see text]mg/kg/day for 8 weeks increased the levels of alanine aminotransferase (ALT) and blood urea nitrogen (BUN). However, such increases were attenuated by the treatment of 20(R)-Rg3 for 4 weeks. Meanwhile, 20(R)-Rg3 markedly inhibited D-galactose-caused oxidative stress in liver and kidney. The anti-oxidants, including catalase (CAT) and superoxide dismutase (SOD), were elevated in the mice from 20(R)-Rg3-treated group compared with that from ...Continue Reading

References

Jul 16, 1999·Mechanisms of Ageing and Development·X SongY M Li
Jun 2, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·A K RainaM A Smith
Jan 26, 2008·Chinese Journal of Integrative Medicine·Ping LuQin-liang Hua
May 14, 2008·Current Pharmaceutical Design·Karin Jandeleit-Dahm, Mark E Cooper
Jul 2, 2008·Biological & Pharmaceutical Bulletin·Seong Soo JooDo Ik Lee
Jun 12, 2010·Chinese Medicine·Kar Wah Leung, Alice Sze-Tsai Wong
Dec 8, 2010·The British Journal of Nutrition·Hsiao-Ling ChenChung-Hung Tsai
Apr 4, 2012·Geriatrics & Gerontology International·Kalaiselvi Velayutham AnandPitchairaj Geraldine
Apr 5, 2012·Reproduction in Domestic Animals = Zuchthygiene·N LimanK Gürbulak
Jul 25, 2014·European Journal of Pharmacology·Shaloam Dasari, Paul Bernard Tchounwou
Feb 24, 2016·Frontiers in Pharmacology·Valeria ContiAmelia Filippelli
Mar 5, 2016·Journal of the Chinese Medical Association : JCMA·Linghua LeiXiaoying Yu
Feb 6, 2017·International Immunopharmacology·Jingyao ZhangChang Liu
Apr 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Nan HuYing-Ping Wang
Jul 5, 2017·Experimental and Therapeutic Medicine·Zhaoying DongYaping Wang
Sep 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingang HouChulhee Choi
May 4, 2018·Food & Nutrition Research·Huandong ZhaoYuxiang Chen
Apr 11, 2019·The American Journal of Chinese Medicine·Hsiu-Chung OuChih-Yang Huang
May 17, 2019·The American Journal of Chinese Medicine·Dae-Young LeeKwang-Soon Shin
Dec 5, 2019·The American Journal of Chinese Medicine·Han XiaoJunling Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis