Rare PIK3CA hotspot mutations in carcinomas of the biliary tract

Genes, Chromosomes & Cancer
Marc-Oliver RienerWolfram Jochum

Abstract

Somatic mutations of the PIK3CA gene, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), are frequent in various cancer types. The majority of mutations cluster at hotspots within exons 9 and 20, which encode the helical and kinase domains of p110alpha. PIK3CA mutations in bile duct and gallbladder carcinomas have not been reported yet. In this study, we analysed 118 carcinomas of the biliary tract and the liver (45 intra- and extrahepatic cholangiocarcinomas (CCA), 23 gallbladder carcinomas, 50 hepatocellular carcinomas) for PIK3CA hotspot mutations using polymerase chain reaction and direct DNA sequencing. PIK3CA missense mutations were found in one of 11 intrahepatic CCA (E545K, 9%), one of 23 gallbladder carcinomas (E542K, 4%), and one of 50 hepatocellular carcinomas (H1047R, 2%). All three mutations represent hotspot mutations, which also occur in other cancer types. PI3K pathway activation in hepato-biliary carcinomas was analyzed using immunohistochemistry for the downstream targets eIF4-E and phosphorylated 4E-BP1 on tissue microarrays. eIF4-E expression was found in 3/13 intrahepatic CCA (23%), 9/38 extrahepatic CCA (24%), 12/34 gallbladder carcinomas (35%), and 9/61 hepatocellular c...Continue Reading

References

Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Mar 16, 2004·Science·Yardena SamuelsVictor E Velculescu
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sohye KangPeter K Vogt
May 12, 2005·Gastroenterology·Konstantinos N Lazaridis, Gregory J Gores
Jun 3, 2005·Cancer Research·Tsuneo IkenoueMasao Omata
Jun 14, 2005·Cancer Cell·Yardena SamuelsVictor E Velculescu
Oct 11, 2005·Lancet·Shahid A KhanSimon D Taylor-Robinson
Dec 13, 2005·Nature Reviews. Cancer·Andreas G BaderPeter K Vogt
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andreas G BaderPeter K Vogt
Feb 2, 2006·British Journal of Cancer·B KarakasB H Park
Jun 13, 2006·The Journal of Clinical Investigation·Xiaoling XuChu-Xia Deng
Sep 21, 2006·Journal of Gastroenterology and Hepatology·Milind M JavleMichael G Brattain
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandrine BoyaultJessica Zucman-Rossi

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Citations

Jun 15, 2011·Pathology Oncology Research : POR·Xun LiZhongtian Bai
Mar 8, 2012·Current Opinion in Gastroenterology·Jesper B Andersen, Snorri S Thorgeirsson
Feb 10, 2011·BMC Cancer·Vikram DeshpandeAram F Hezel
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aram F HezelAndrew X Zhu
Feb 12, 2010·The Oncologist·Andrew X ZhuDavid A Kooby
Apr 29, 2014·Hepatic Oncology·Jesper B Andersen, Snorri S Thorgeirsson
Sep 6, 2014·Breast Cancer Research : BCR·Dimitrios ZardavasSherene Loi
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Niraj KumariVinay Kumar Kapoor
Nov 6, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rui Feng XuWang Jun Liao
Mar 8, 2016·The Journal of Molecular Diagnostics : JMD·Ivan RoaMilind Javle
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc-Oliver RienerGlen Kristiansen
Feb 10, 2012·Journal of Hepato-biliary-pancreatic Sciences·Jason E Faris, Andrew X Zhu
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrew X Zhu, Aram F Hezel
Sep 23, 2011·Journal of Cellular Physiology·Yingwei ChenYongtao Xiao
Mar 29, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dong Choon KimSun Young Kwon
Sep 2, 2014·Journal of Hepato-biliary-pancreatic Sciences·Jesper B Andersen
May 3, 2014·Journal of Gastroenterology and Hepatology·Jimme K WiggersThomas M van Gulik
Dec 22, 2009·Leukemia Research·Said I IsmailMaher A Sughayer
Oct 1, 2015·International Journal of Genomics·Pattaya SeereeTavan Janvilisri
Jul 20, 2012·Critical Reviews in Oncology/hematology·Donatella MarinoMassimo Aglietta
Feb 15, 2015·Virchows Archiv : an International Journal of Pathology·Andrea P MoyVikram Deshpande
Feb 19, 2015·Current Opinion in Gastroenterology·Iván Roa, Xabier de Aretxabala
Feb 3, 2015·Cancer Treatment Reviews·Carolina BizamaJuan Carlos Roa
May 28, 2013·Yonsei Medical Journal·Heesue KimHo Yeong Lim
Feb 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ebubekir DiricanAyşe Özer
Mar 11, 2017·Expert Opinion on Therapeutic Targets·Jennifer YangGregory B Lesinski
Aug 30, 2008·British Journal of Cancer·M-O RienerW Jochum
Sep 21, 2011·The American Journal of Gastroenterology·Pawel K MazurJens T Siveke
Oct 30, 2018·Journal of Cellular Physiology·Jayaramayya KaavyaVellingiri Balachandar
Oct 27, 2015·Oncotarget·Seung Tae KimJoon Oh Park
Jan 29, 2016·World Journal of Gastroenterology : WJG·Eric I Marks, Nelson S Yee
Oct 12, 2018·NPJ Precision Oncology·James M BogenbergerMitesh J Borad
Mar 25, 2014·Oncotarget·Andrea LunardiPier Paolo Pandolfi
Jan 27, 2019·International Journal of Molecular Sciences·Chao-En WuChun-Nan Yeh
Apr 19, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Colm J O'RourkeJesper B Andersen
Dec 6, 2020·Journal of Cellular and Molecular Medicine·Mingxun WangGang Chen

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