PMID: 11921274Mar 29, 2002Paper

Rare recurring balanced chromosome abnormalities in therapy-related myelodysplastic syndromes and acute leukemia: report from an international workshop

Genes, Chromosomes & Cancer
AnneMarie W BlockMaria R Baer

Abstract

Seventy-seven patients were identified with Rare recurring (excluding 11q23, 21q22, inv(16), and t(15;17)) chromosome abnormalities among 511 patients with treatment-related myelodysplastic syndromes and acute leukemia accepted from centers in the United States, Europe, and Japan. The abnormality subsets included 3q21q26 (17 patients), 11p15 (17 patients), t(9;22)(q34;q11) (10 patients), 12p13 (9 patients), t(8;16)(p11;p13) (9 patients), and an "other" subset, which included t(6;9)(p23;q34) (3 patients), t(10;11)(p13;q13 approximately q21) (3 patients), t(1;17)(p36;q21) (2 patients), t(8;14)(q24;q32) (2 patients), t(11;19)(q13;q13) (2 patients), t(1;3)(p36;q21) (2 patients), and t(3;5)(q21;q31) (1 patient). Increased karyotypic complexity with additional balanced and unbalanced rearrangements was observed in 70% of cases. Among 54 cases with secondary abnormalities, chromosome 5 and/or 7 abnormalities were observed in 59%. The most frequent primary diseases were breast cancer (24 cases), Hodgkin disease (14 cases), non-Hodgkin lymphoma (10 cases), and de novo ALL (5 cases). Thirty-seven patients received alkylating agents plus topoisomerase II inhibitors with or without radiation therapy. The presenting diagnosis was t-AML in 4...Continue Reading

References

Jul 15, 1979·International Journal of Cancer. Journal International Du Cancer·F MitelmanP G Nilsson
Aug 1, 1991·Cancer Genetics and Cytogenetics·J Pedersen-Bjergaard, P Philip
Feb 1, 1986·Cancer Genetics and Cytogenetics·J G SchwartzL Manhoff
Apr 1, 1985·American Journal of Hematology·M G PearsonE L Prigogina
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M H DreylingS K Bohlander
Feb 14, 1998·Cancer Genetics and Cytogenetics·P TemperaniG Emilia
Aug 25, 1999·Annals of Hematology·C F WallerW Lange
Aug 5, 2000·Genes, Chromosomes & Cancer·L MichauxA Hagemeijer
Dec 6, 2001·Cancer Genetics and Cytogenetics·P C NathanD Malkin

❮ Previous
Next ❯

Citations

Mar 10, 2005·Journal of Clinical Laboratory Analysis·Roger S RileyJonathan M Ben-Ezra
Jan 17, 2004·Biochimie·Peter KarranMargherita Bignami
Jan 16, 2003·Leukemia Research·David P Steensma, Ayalew Tefferi
Sep 9, 2008·Journal of Pediatric Hematology/oncology·Tadashi MatsubayashiJun Miyahara
Jul 27, 2005·Annals of Hematology·Serena De VitaSimona Sica
May 13, 2005·Mayo Clinic Proceedings·David P Steensma, Alan F List
Jun 16, 2010·European Journal of Haematology·Naoya MimuraKyoya Kumagai
Jun 21, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Takeshi TaketaniSeiji Yamaguchi
Nov 1, 2005·Trends in Genetics : TIG·Peter D Aplan
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ling ZhangRami Komrokji
Aug 19, 2009·American Journal of Clinical Pathology·Magdalena Czader, Attilio Orazi
Nov 20, 2016·American Journal of Hematology·Ibrahim AldossVinod Pullarkat
Jul 27, 2021·Clinics in Laboratory Medicine·Gerald Wertheim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.