Rare suprasellar glioblastoma: report of two cases and review of the literature

Brain Tumor Pathology
Doreen LemmElisabeth J Rushing

Abstract

The suprasellar and hypothalamic/chiasmatic regions can harbor a broad range of pathologic conditions, both neoplastic and nonneoplastic; however, malignant gliomas are extremely rare in those regions. Patient 1 was a 70 year-old man with weight loss and rapidly progressive visual impairment. A mass centered in the hypothalamus was detected on magnetic resonance (MR) imaging. The second patient, a 45 year-old woman, complained of visual symptoms and headaches. MR imaging revealed a combined intra- and suprasellar mass. In both instances, the preoperative differential diagnosis favored craniopharyngioma. Histological examination confirmed the diagnosis of glioblastoma. We report two rare adult cases of hypothalamic/chiasmatic glioblastoma. The authors review the literature, highlighting the importance of considering this rare entity in the differential diagnosis of suprasellar and hypothalamic lesions.

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Citations

Aug 21, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kuntal Kanti DasRaj Kumar
Jul 22, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Colin Raelson, Gloria Chiang

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