PMID: 9163616May 1, 1997Paper

Rarity of microsatellite genomic instability in B-cell non-Hodgkin's lymphomas in hepatitis C virus-infected patients

British Journal of Haematology
S De VitaM Boiocchi

Abstract

Several groups have emphasized the likely implication of the hepatitis C virus (HCV) in a fraction of B-cell non-Hodgkin's lymphomas. Since only a minority of patients with HCV infection and monoclonal mixed cryoglobulinaemia develop overt lymphoma, the identification of predisposing factors has relevant clinical implications. The replication error phenotype (RER+), as revealed by widespread microsatellite instability, is caused by defects in DNA mismatch repair genes, and has been frequently disclosed in subsets of B-cell lymphomas with underlying infection and chronic inflammation. We therefore investigated the occurrence of the RER+ phenotype in a series of eight consecutive B-cell NHLs in patients with chronic infection by HCV. A polymerase chain reaction-based assay was used to analyse an extended panel of 15 microsatellite loci. Microsatellite instability was not observed in six tumour samples in any locus; the two remaining cases showed instability at only one locus. Therefore genetic instability by defects in DNA mismatch repair genes should not represent the general mechanism predisposing to overt lymphoma in HCV-infected patients. Although a clearer definition of HCV-related B-cell disorders should better address futu...Continue Reading

Citations

Aug 4, 2001·Human Pathology·M P DoreA R Sepulveda
Jan 8, 2008·Leukemia Research·Kaname MiyashitaNaokuni Uike
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Daniel ReJürgen Wolf
Aug 18, 2005·International Journal of Cancer. Journal International Du Cancer·Clara SambadeChrister Sundström
Apr 13, 2000·Japanese Journal of Cancer Research : Gann·T TakakuwaK Aozasa
Sep 1, 1999·Seminars in Arthritis and Rheumatism·J E NaschitzD Yeshurun

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