Ras moves to stay in place

Trends in Cell Biology
Malte SchmickPhilippe I H Bastiaens

Abstract

Ras is a major intracellular signaling hub. This elevated position comes at a precarious cost: a single point mutation can cause aberrant signaling. The capacity of Ras for signaling is inextricably linked to its enrichment at the plasma membrane (PM). This PM localization is dynamically maintained by three essential elements: alteration of membrane affinities via lipidation and membrane-interaction motifs; trapping on specific membranes coupled with unidirectional vesicular transport to the PM; and regulation of diffusion via interaction with a solubilization factor. This system constitutes a cycle that primarily corrects for the entropic equilibration of Ras to all membranes that dilutes its signaling capacity. We illuminate how this reaction-diffusion system maintains an out-of-equilibrium localization of Ras GTPases and thereby confers signaling functionality to the PM.

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J H JacksonC J Der
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·V ManneH F Kung
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J CaseyJ E Buss
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S ClarkeJ Stock
Nov 1, 1984·Nature·P H SeeburgA D Levinson
Jan 22, 1998·Current Opinion in Structural Biology·M Geyer, A Wittinghofer
Jun 17, 1998·The Journal of Biological Chemistry·Q DaiM R Philips
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·W K SchmidtS Michaelis
Mar 20, 1999·The Journal of Biological Chemistry·J C OttoP J Casey
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·M SchlitzerP J Casey
May 1, 2002·The EMBO Journal·Michael Hanzal-BayerRoman C Hillig
Jul 19, 2003·Genes & Development·Ken InokiKun-Liang Guan
Feb 12, 2005·Science·Oliver RocksPhilippe I H Bastiaens
Mar 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ann M Winter-VannPatrick J Casey
Jul 20, 2005·The Journal of Cell Biology·J Shawn GoodwinAnne K Kenworthy
Mar 2, 2006·Molecular Cell·Natalia JuraDafna Bar-Sagi
Aug 8, 2006·Molecular Cancer Therapeutics·Charles E DuckerCharles D Smith
May 24, 2008·Science·Yasemin SancakDavid M Sabatini
Jun 10, 2008·Current Medicinal Chemistry·Sérgio F SousaMaria João Ramos
Jun 24, 2008·Nature Reviews. Molecular Cell Biology·Antoine E Karnoub, Robert A Weinberg
Jul 21, 2009·Molecular Oncology·Nicole FehrenbacherMark Philips
Jan 26, 2010·Current Opinion in Genetics & Development·Ali Kinkhabwala, Philippe I H Bastiaens
Apr 27, 2010·Nature Chemical Biology·Frank J DekkerHerbert Waldmann
Sep 23, 2010·Science Signaling·Anna LorentzenPhilippe I H Bastiaens
Jan 25, 2011·Molecular Cell·Ian M AhearnMark R Philips
Mar 19, 2011·Cell·Hernán E GreccoPhilippe I H Bastiaens
Oct 18, 2011·Nature Chemical Biology·Shehab A IsmailAlfred Wittinghofer
Oct 19, 2011·Future Medicinal Chemistry·Antonio T BainesChanning J Der
Oct 25, 2011·Nature Reviews. Cancer·Norbert BerndtSaïd M Sebti
May 17, 2012·Cancer Research·Ian A PriorCarla Mattos
Nov 6, 2012·The Journal of Biological Chemistry·Kwang-jin ChoJohn F Hancock
Dec 12, 2012·ACS Chemical Biology·Christopher T M B Tom, Brent R Martin

❮ Previous
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Citations

Jan 28, 2016·Chemical Reviews·Shaoyong LuJian Zhang
Jan 7, 2016·Small GTPases·Amanda GarridoNabil Djouder
Dec 29, 2015·Histochemistry and Cell Biology·Qi TianLev M Fedorov
Mar 11, 2016·Physical Chemistry Chemical Physics : PCCP·Nelli ErwinRoland Winter
Jun 27, 2015·Biochimica Et Biophysica Acta·Marc Yeste-VelascoYong-Jie Lu
Apr 21, 2016·Nature Communications·Björn PapkePhilippe I H Bastiaens
Jul 12, 2016·Chemical Society Reviews·Shaoyong LuRuth Nussinov
Jul 15, 2016·Biophysical Journal·Benjamin SperlichKatrin Weise
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Srisathiyanarayanan DharmaiahDhirendra K Simanshu
Jun 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sergii ShydlovskyiChristian Herrmann
Nov 16, 2017·Biological Chemistry·Stefanie Kristine KöslingAlfred Wittinghofer
May 12, 2018·Angewandte Chemie·Petra SchwilleKai Sundmacher
Sep 9, 2018·International Journal of Cancer. Journal International Du Cancer·Christian H KleinPhilippe I H Bastiaens
Jul 4, 2019·Journal of Cell Science·Lingxiao TanJohn F Hancock
Sep 21, 2018·EMBO Reports·Pin-Joe Ko, Scott J Dixon
Feb 20, 2018·Critical Reviews in Biochemistry and Molecular Biology·Saeideh Nakhaei-RadMohammad Reza Ahmadian
Feb 15, 2020·Small GTPases·Verónica Ibáňez GasparChristina Kiel
Jul 13, 2019·Life Science Alliance·Hong LiangYong Zhou
Mar 1, 2017·Biological Chemistry·Klaus GerwertCarsten Kötting
Mar 21, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Aline C GomesThereza Quirico-Santos
Apr 11, 2017·Frontiers in Plant Science·Yaxiao Li, Baoxiu Qi
Aug 18, 2017·BMC Biophysics·H Billur EnginHannah Carter
Aug 17, 2020·The Biochemical Journal·Walaa E Kattan, John F Hancock
Sep 7, 2018·BioMed Research International·Aswin T SrivatsavShobhna Kapoor
Dec 19, 2018·Biochemical Society Transactions·François PeuroisJacqueline Cherfils
Jun 11, 2020·F1000Research·Brittany Angarola, Shawn M Ferguson
Jul 26, 2017·Nature Communications·Antonios D KonitsiotisPhilippe I H Bastiaens
Dec 6, 2018·International Journal of Molecular Sciences·Matteo SpinelliClaudio Grassi
Nov 8, 2018·Nature Communications·Takero MiyagawaMasahiro Ueda
Nov 12, 2020·Biomolecules·Daniel Abankwa, Alemayehu A Gorfe
Feb 11, 2021·Biomolecules·Christina KielWalter Kolch
Oct 24, 2020·Journal of Cellular Physiology·Jiayu JinDan Meng
Nov 7, 2020·Biochemical Society Transactions·Jasmine CornishHelen R Mott
Apr 2, 2021·Plant Physiology·Marija SmokvarskaAlexandre Martinière
Jul 6, 2021·Frontiers in Molecular Biosciences·Yong ZhouJohn F Hancock
Aug 5, 2021·Oncogene·Jiuna ZhangHuiqing Jiang
Aug 9, 2021·Current Opinion in Structural Biology·Sharon L Campbell, Mark R Philips
May 8, 2018·ACS Chemical Biology·Sang Joon Won, Brent R Martin
Jul 1, 2020·Journal of Medicinal Chemistry·Junfei ChengChunquan Sheng

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