PMID: 7542226Apr 21, 1995Paper

ras, p53 and HPV status in benign and malignant prostate tumors

International Journal of Cancer. Journal International Du Cancer
C Moyret-LalleC Theillet

Abstract

To study the role of ras, p53 genes and HPV virus (16 and 18) in the development of prostate cancer, we analyzed tissue sections from 27 patients affected with carcinomas (stages A to D) and from 24 patients with adenomas. Mutations of H, K and N-ras and p53 (exons 2-9) were studied by SSCP and DNA sequencing. Accumulation of p53 protein was studied by immunohistochemistry on tissue sections. Tumors were also analyzed for the presence of HPV16 and -18 sequences by PCR and DNA hybridization with sequence-specific oligonucleotides. No mutation was found in the three ras genes studied, either in carcinomas or adenomas. By SSCP analysis we identified p53 mutations in only 2 of 19 carcinomas studied, both in exon 7. Immunohistochemical results strongly correlate with the SSCP results: p53 protein was positive in tumors with p53 mutation but not in others; 32% of studied adenomas had detectable HPV16 DNA, while 53% of carcinomas were HPV16+. Among these I presented a p53 mutation. No HPV18 E6 sequence could be detected. Our data show that in prostate tumors from France, mutations of p53 and ras are rare events but that these tumors display detectable HPV16 DNA at a high frequency. The low incidence of p53 mutation, associated to a si...Continue Reading

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Citations

Mar 15, 2011·Irish Journal of Medical Science·Y LinL Xie
Oct 11, 2003·Urology·Jasminka PavelićMaja Herak Bosnar
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A KuczykU Jonas
Mar 1, 1997·Urologic Oncology·Y Z Wang, Y C Wong
Jan 9, 2004·Epidemiology·Rosebud O RobertsSteven J Jacobsen
Jul 29, 2010·Scandinavian Journal of Infectious Diseases·Arezoo AghakhaniAmitis Ramezani
Mar 23, 2010·Cancer Genetics and Cytogenetics·Yanying ShenJianshan Zhu
Nov 8, 2008·The American Journal of Pathology·Faris FarassatiAndreas Kurtz
May 13, 2008·Medical Hypotheses·Ala-Eddin Al Moustafa
Dec 7, 2007·The Urologic Clinics of North America·David StockD Robert Siemens
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Sep 4, 2015·Infectious Agents and Cancer·Hector RodríguezFrancisco Aguayo
Aug 2, 2014·Asian Journal of Andrology·Yao ZhuDing-Wei Ye
Sep 29, 2005·Biochemical and Biophysical Research Communications·Naohiro TsuyamaHideaki Ishikawa
Feb 27, 1999·Endocrine Reviews·E RuijterJ Schalken
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·J DillnerA Aromaa
Aug 10, 2017·Oncology Letters·Binbin YinZhihua Tao
Jul 21, 2020·Infectious Agents and Cancer·James S Lawson, Wendy K Glenn
Apr 22, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Atike BahcivanBinnur Onal

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