PMID: 30154091DOI: 10.1042/bst20170529Aug 30, 2018Paper
Ras proteins as therapeutic targets
Biochemical Society Transactions
Atanu ChakrabortySarah Ross
Abstract
Oncogenic mutations in RAS genes underlie the pathogenesis of many human tumours, and there has been intense effort for over 30 years to develop effective and tolerated targeted therapeutics for patients with Ras-driven cancers. This review summarises the progress made in Ras drug discovery, highlighting some of the recent developments in directly targeting Ras through advances in small molecule drug design and novel therapeutic strategies.
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Citations
Jan 22, 2020·The Journal of Biological Chemistry·George J N TetleyDarerca Owen
Nov 27, 2020·Biochemical Society Transactions·Atanu Chakraborty
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