Ras proteins as therapeutic targets

Biochemical Society Transactions
Atanu ChakrabortySarah Ross

Abstract

Oncogenic mutations in RAS genes underlie the pathogenesis of many human tumours, and there has been intense effort for over 30 years to develop effective and tolerated targeted therapeutics for patients with Ras-driven cancers. This review summarises the progress made in Ras drug discovery, highlighting some of the recent developments in directly targeting Ras through advances in small molecule drug design and novel therapeutic strategies.

References

Aug 18, 1994·Nature·P Rodriguez-VicianaJ Downward
May 30, 1997·The Journal of Biological Chemistry·D B WhyteJ K Pai
Oct 20, 1998·Oncogene·C HerrmannO Müller
Aug 10, 1999·Nature·L ChinR A DePinho
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Van CutsemD Von Hoff
Apr 13, 2007·Biochimica Et Biophysica Acta·Krishnaraj RajalingamStefan Albert
Jul 19, 2011·Nature Chemical Biology·Anupam PatgiriDafna Bar-Sagi
Jan 11, 2012·The Journal of Clinical Investigation·Meredith A CollinsMarina Pasca di Magliano
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Till MaurerGuowei Fang
May 10, 2012·Accounts of Chemical Research·Lígia C Gomes-da-SilvaJoão N Moreira
May 17, 2012·Cancer Research·Ian A PriorCarla Mattos
Nov 8, 2012·Nature Communications·Hao-Hsuan JengDafna Bar-Sagi
Nov 22, 2013·Angewandte Chemie·Sang Min LimNathanael S Gray
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Elina Zorde KhvalevskyEithan Galun
Aug 8, 2014·Cancer Discovery·Tina L YuanScott W Lowe
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wen XueTyler Jacks
Oct 5, 2014·Molecular Cancer Therapeutics·Chad V PecotAnil K Sood
Oct 18, 2014·Nature Reviews. Drug Discovery·Adrienne D CoxChanning J Der
Dec 3, 2014·Chemistry & Biology·Chris R EvelynYi Zheng
Jan 8, 2015·Frontiers in Bioengineering and Biotechnology·Alessandro LaganàCarlo Maria Croce
Jan 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Li LiuAxel Hoos
Jan 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sebastian BäumerCarsten Müller-Tidow
Feb 20, 2015·Journal of Medicinal Chemistry·Jon J G WinterGail Wrigley
Apr 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alec C Kimmelman
Sep 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth K ZiemkeJudith S Sebolt-Leopold

❮ Previous
Next ❯

Citations

Nov 27, 2020·Biochemical Society Transactions·Atanu Chakraborty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.