ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex

The EMBO Journal
C MuchardtM Yaniv

Abstract

The brm and BRG-1 proteins are mutually exclusive subunits of the mammalian SWI-SNF complex. Within this complex, they provide the ATPase activity necessary for transcriptional regulation by nucleosome disruption. Both proteins were recently found to interact with the p105Rb tumor suppressor gene product, suggesting a role for the mammalian SWI-SNF complex in the control of cell growth. We show here that the expression of brm, but not BRG-1, is negatively regulated by mitogenic stimulation, and that growth arrest of mouse fibroblasts leads to increased accumulation of the brm protein. The expression of this protein is also down-regulated upon transformation by the ras oncogene. Re-introduction of brm into ras transformed cells leads to partial reversion of the transformed phenotype by a mechanism that depends on the ATPase domain of the protein. Our data suggest that increased levels of brm protein favour the withdrawal of the cell from the cycle whereas decreased expression of the brm gene may facilitate cellular transformation by various oncogenes.

References

Nov 2, 1988·Journal of the National Cancer Institute·C SpinucciH Nagase
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M NodaR H Bassin
Aug 1, 1995·Current Opinion in Genetics & Development·J W Tamkun
Apr 1, 1995·Current Opinion in Genetics & Development·V Orlando, R Paro
Jun 1, 1994·Current Opinion in Cell Biology·M Carlson, B C Laurent
Aug 11, 1994·Nature·A N ImbalzanoR E Kingston
Apr 1, 1996·Current Opinion in Genetics & Development·C L Peterson
Sep 1, 1996·Genes & Development·W WangG R Crabtree
Feb 7, 1997·Biochimica Et Biophysica Acta·L G Burns, C L Peterson
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·D TroucheT Kouzarides

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Citations

Jan 16, 2002·Current Opinion in Genetics & Development·Agnès Klochendler-YeivinMoshe Yaniv
Dec 13, 2005·Nature Structural & Molecular Biology·Eric BatschéChristian Muchardt
Aug 19, 2007·Oncogene·S MujtabaM-M Zhou
May 21, 1999·European Journal of Biochemistry·B GeliusA K Ostlund Farrants
Jul 3, 2002·The EMBO Journal·Anthony M BrumbyHelena Richardson
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Angelina Stojanova, Linda Z Penn
Sep 1, 2007·BMC Molecular Biology·Roger FerreiraPeter B Becker
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·M NagaiK Nagashima
May 16, 2014·Cancer Genetics·Moshe Yaniv
Feb 12, 2010·Stem Cell Reviews and Reports·Srinivas Vinod Saladi, Ivana L de la Serna
Sep 13, 2001·Biochimica Et Biophysica Acta·A Klochendler-Yeivin, M Yaniv
May 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E H RaabeR J Arceci
Feb 24, 2009·Oncogene·D ReismanE A Thompson
Jul 18, 2015·Genes·Angélique Galvani, Christophe Thiriet
Jun 18, 2010·Experimental Cell Research·Sonia Albini, Pier Lorenzo Puri
Jul 6, 2012·The Journal of Investigative Dermatology·Vladimir A BotchkarevMichael Y Fessing
Dec 6, 2003·The EMBO Journal·Brigitte BourachotChristian Muchardt
Dec 20, 2008·Journal of Cellular Physiology·Bridget Keenen, Ivana L de la Serna
May 25, 2010·The British Journal of Dermatology·H LinG Li
Mar 27, 2015·Journal of Cellular Physiology·Qiong WuAnthony N Imbalzano
Jun 15, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Srinivas Vinod SaladiIvana L de la Serna
Mar 21, 2000·Genesis : the Journal of Genetics and Development·T C GebuhrT Magnuson
Dec 6, 2001·The Journal of Biological Chemistry·Hiroyuki KatoRobert G Roeder
Sep 7, 2004·The Journal of Biological Chemistry·Feng WangOliver Hankinson
Apr 30, 2008·FEBS Letters·Ann-Kristin Ostlund Farrants
Mar 26, 2002·FEBS Letters·Lei Zeng, Ming Ming Zhou
Feb 3, 2018·Scientific Reports·Jose A Guerrero-Martínez, Jose C Reyes
Aug 22, 2007·Journal of Cellular Physiology·Sharmistha Pal, Saïd Sif

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