Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.

Genetics
M BoubeD L Cribbs

Abstract

Mutations of the Drosophila homeotic proboscipedia gene (pb, the Hox-A2/B2 homologue) provoke dose-sensitive defects. These were used to search for dose-sensitive dominant modifiers of pb function. Two identified interacting genes were the proto-oncogene Ras1 and its functional antagonist Gap1, prominent intermediaries in known signal transduction pathways. Ras1+ is a positive modifier of pb activity both in normal and ectopic cell contexts, while the Ras1-antagonist Gap1 has an opposite effect. A general role for Ras1 in homeotic function is likely, since Ras1+ activity also modulates functions of the homeotic loci Sex combs reduced and Ultrabithorax. Our data suggest that the modulation occurs by a mechanism independent of transcriptional control of the homeotic loci themselves, or of the Ras1/Gap1 genes. Taken together our data support a role for Ras1-mediated cell signaling in the homeotic control of segmental differentiation.

Citations

Feb 4, 2006·Molecular & Cellular Proteomics : MCP·Sarah E BondosKathleen S Matthews
Feb 12, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brian L Florence, Douglas V Faller
Nov 21, 2001·Nature Reviews. Genetics·J P Kumar
Dec 5, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Colin N Moran, Charalambos P Kyriacou

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