Rasagiline for the symptomatic treatment of fatigue in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Thien Thien LimHubert H Fernandez

Abstract

Fatigue affects 40% to 50% of all PD patients and is a leading cause of disability, with no clearly established or efficacious established treatments. In this double-blinded, placebo-controlled, pilot trial, we investigated whether rasagiline improved fatigue among PD patients. Subjects were randomized to 1 mg daily of rasagiline or placebo for 12 weeks. The primary endpoint was a change in the Modified Fatigue Impact Scale from baseline to week 12. Thirty PD subjects (16 men), with Modified Fatigue Impact Scale baseline score of 67 ± 15, were randomized (16 to rasagiline vs. 14 to placebo). Significant improvement was noted in the mean Modified Fatigue Impact Scale score of the rasagiline group (12 points) as compared to placebo (8.5 points) from baseline to week 12 (P = 0.003). In this pilot study, rasagiline at a dose of 1 mg per day improved fatigue. Larger randomized studies are needed to confirm this finding.

References

Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·S E StarksteinR G Robinson
Aug 1, 1995·Journal of Clinical and Experimental Neuropsychology·G J Larrabee, G Curtiss
Apr 1, 1995·Journal of Psychosomatic Research·E M SmetsJ C De Haes
Apr 1, 1994·Perception & Psychophysics·C E CollyerR M Church
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D FiskW F Schlech
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·J J van HiltenR A Roos
Oct 1, 1993·Neurology·J Friedman, H Friedman
Mar 16, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·S PaiJ A Ship
Oct 30, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Steven R SchwidMichael P McDermott
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Nov 30, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph H FriedmanUNKNOWN Working Group on Fatigue in Parkinson's Disease
Dec 6, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Florian FerreriSerge Gauthier
Mar 14, 2007·Archives of Neurology·John G NuttNichole E Carlson
Apr 24, 2007·Journal of Neural Transmission. Supplementum·A H V Schapira
Jul 12, 2007·Multiple Sclerosis : Clinical and Laboratory Research·D KosE Kerckhofs
Feb 16, 2008·Neuromolecular Medicine·Teresa E Foley, Monika Fleshner
Aug 13, 2008·Neurology·G SchifittoUNKNOWN Parkinson Study Group ELLDOPA Investigators
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Holger HonigK Ray Chaudhuri
May 26, 2010·Journal of Applied Biomechanics·Ziad D Alkurdi, Yazan M Dweiri
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Robert A HauserWerner Poewe
Oct 7, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Karl Kieburtz, UNKNOWN Parkinson Study Group PramiBID Investigators
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Charlotte WinwardHelen Dawes
Oct 4, 2011·Internal Medicine·Akihiko MoritaKoichi Hirata
Mar 14, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Louise M McDonaldMarjan Jahanshahi
Dec 19, 2012·Parkinsonism & Related Disorders·Dawn M SchiehserJ Vincent Filoteo
Jan 24, 2014·International Journal of MS Care·Rebecca D Larson

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Citations

Jan 15, 2017·Journal of the Neurological Sciences·Karen Herlofson, Benzi M Kluger
Jan 17, 2017·Journal of the Neurological Sciences·Kaylena A Ehgoetz Martens, Simon J G Lewis
May 31, 2018·British Journal of Clinical Pharmacology·C D BindeM Klemp
Sep 29, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Mattia SicilianoAlessandro Tessitore
Jan 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiUNKNOWN the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders So
Apr 16, 2020·Expert Review of Neurotherapeutics·Claudia Lazcano-OcampoK Ray Chaudhuri
Apr 5, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Anna CastriotoPaul Krack
Dec 14, 2017·International Journal of Geriatric Psychiatry·Kelly A MillsGregory M Pontone
Jun 27, 2019·Expert Review of Neurotherapeutics·Isabella BerardelliGiovanni Fabbrini
Jun 17, 2019·The Medical Journal of Australia·Michael W HayesJohn D O'Sullivan
May 31, 2019·Journal of Neural Transmission·Anna Nagy, Anette Schrag
Feb 7, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Daniel V Nassif, João S Pereira
Jul 13, 2018·Journal of Translational Medicine·Raymond ChongJohn Morgan
Aug 26, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·De-Qi JiangYong Wang
Aug 14, 2021·Clinical Neurology and Neurosurgery·Haili WangYingzhu Chen

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