PMID: 25735335Mar 5, 2015Paper

RASAL1 attenuates gastric carcinogenesis in nude mice by blocking RAS/ERK signaling

Asian Pacific Journal of Cancer Prevention : APJCP
Hong ChenZhi Wang

Abstract

Recent studies have suggested that the RAS protein activator like-1 (RASAL1) functions as a tumor suppressor in vitro and may play an important role in the development of gastric cancer. However, whether or not RASAL1 suppresses tumor growth in vivo remains to be determined. In the present study, we investigated the role of RASAL1 in gastric carcinogenesis using an in vivo xenograft model. A lentiviral RASAL1 expression vector was constructed and utilized to transfect the human poorly differentiated gastric adenocarcinoma cell line, BGC-823. RASAL1 expression levels were verified by quantitative real-time RT-PCR and Western blotting analysis. Then, we established the nude mice xenograft model using BGC-823 cells either over-expressing RASAL1 or normal. After three weeks, the results showed that the over-expression of RASAL1 led to a significant reduction in both tumor volume and weight compared with the other two control groups. Furthermore, in xenograft tissues the increased expression of RASAL1 in BGC-823 cells caused decreased expression of p-ERK1/2, a downstream moleculein the RAS/RAF/MEK/ERK signal pathway. These findings demonstrated that the over-expression of RASAL1 could inhibit the growth of gastric cancer by inactiva...Continue Reading

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Citations

Sep 12, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xinmeng QiGuangxin Zhang
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lijun MaHongquan Zhang
May 21, 2019·Open Life Sciences·Rui-Xia ChangCong-Xiu Miao
Oct 8, 2020·European Neurology·Guanchuan LinXinghua Pan

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