Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(©) )

Journal of the Peripheral Nervous System : JPNS
Els K VanhouttePeriNomS Study Group

Abstract

Clinical trials in multifocal motor neuropathy (MMN) have often used ordinal-based measures that may not accurately capture changes. We aimed to construct a disability interval outcome measure specifically for MMN using the Rasch model and to examine its clinimetric properties. A total of 146 preliminary activity and participation items were assessed twice (reliability studies) in 96 clinically stable MMN patients. These patients also assessed the ordinal-based overall disability sum score (construct, sample-dependent validity). The final Rasch-built overall disability scale for MMN (MMN-RODS(©) ) was serially applied in 26 patients with newly diagnosed or relapsing MMN, treated with intravenous immunoglobulin (IVIg) (1-year follow-up; responsiveness study). The magnitude of change for each patient was calculated using the minimum clinically important difference technique related to the individually obtained standard errors. A total of 121 items not fulfilling Rasch requirements were removed. The final 25-item MMN-RODS(©) fulfilled all Rasch model's expectations and showed acceptable reliability and validity including good discriminatory capacity. Most serially examined patients improved, but its magnitude was low, reflecting p...Continue Reading

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Citations

Mar 2, 2016·Journal of the Peripheral Nervous System : JPNS
Jun 27, 2015·Journal of the Peripheral Nervous System : JPNS·Mariëlle H J PruppersUNKNOWN PeriNomS study group
Jun 26, 2015·Journal of the Peripheral Nervous System : JPNS·Thomas H P DraakUNKNOWN PeriNomS Study Group
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Feb 13, 2019·Journal of the Peripheral Nervous System : JPNS·Ali Al-ZuhairyJohannes Jakobsen
Apr 21, 2020·Muscle & Nerve·Yusuf A RajaballyHans-Peter Hartung
May 30, 2020·Journal of the Peripheral Nervous System : JPNS·Pietro Emiliano DonedduEduardo Nobile-Orazio
Aug 27, 2015·Journal of the Peripheral Nervous System : JPNS·Peter Y K Van den Bergh, Michael P Lunn
Jan 22, 2020·Neurology·Ingrid J T HerraetsW Ludo van der Pol
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Apr 23, 2020·Muscle & Nerve·Pietro E Doneddu, Robert D M Hadden
Mar 21, 2021·Neuromuscular Disorders : NMD·Tatiana HamadehIngemar S J Merkies

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