RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?

Molecular Biology International
Simon F Scrace, Eric O'Neill

Abstract

The RASSF family of proteins has been extensively studied in terms of their genetics, structure and function. One of the functions that has been increasingly studied is the role of the RASSF proteins in the DNA damage response. Surprisingly, this research, which encompasses both the classical and N-terminal RASSF proteins, has revealed an involvement of the RASSFs in oncogenic pathways as well as the more familiar tumour suppressor pathways usually associated with the RASSF family members. The most studied protein with respect to DNA damage is RASSF1A, which has been shown, not only to be activated by ATM, a major regulator of the DNA damage response, but also to bind to and activate a number of different pathways which all lead to and feedback from the guardian of the genome, p53. In this review we discuss the latest research linking the RASSF proteins to DNA damage signalling and maintenance of genomic integrity and look at how this knowledge is being utilised in the clinic to enhance the effectiveness of traditional cancer therapies such as radiotherapy.

References

Sep 15, 1995·The Journal of Biological Chemistry·C L Creasy, J Chernoff
Jun 28, 1995·JAMA : the Journal of the American Medical Association·R I Shorr, W L Greene
Aug 19, 1993·The New England Journal of Medicine·T G KrontirisN Risch
Sep 1, 1995·Current Biology : CB·A C Newton
Aug 30, 1996·The Journal of Biological Chemistry·C L CreasyJ Chernoff
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·L K TaylorR L Erikson
Nov 1, 1996·Trends in Biochemical Sciences·C P Ponting, D R Benjamin
May 15, 1997·Nature·Y HauptM Oren
May 15, 1997·Nature·M H KubbutatK H Vousden
Apr 16, 1998·The Journal of Biological Chemistry·D VavvasX F Zhang
Sep 18, 1998·Biochimica Et Biophysica Acta·Y SekidoJ D Minna
Nov 2, 1999·Journal of Biochemistry·T YamamotoK Kaibuchi
Dec 23, 1999·The Journal of Biological Chemistry·S T KimM B Kastan
Dec 1, 2000·Nature·B VogelsteinA J Levine
Mar 15, 2001·Current Opinion in Cell Biology·D Durocher, S P Jackson
May 3, 2001·Journal of the National Cancer Institute·D G BurbeeJ D Minna
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·K DreijerinkE R Zabarovsky
May 25, 2002·Molecular and Cellular Biology·Latha ShivakumarMichael A White
Sep 12, 2002·The Journal of Biological Chemistry·Helmut GlantschnigAlfred A Reszka
Jan 1, 2003·Seminars in Cancer Biology·Dan Michael, Moshe Oren
May 7, 2003·The Journal of Biological Chemistry·Michele D VosGeoffrey J Clark
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Hideki EndohTetsuya Mitsudomi
Nov 25, 2003·The Journal of Biological Chemistry·Gerry MelinoKaren H Vousden
Dec 4, 2003·Mutation Research·Elza T Sakamoto-HojoGeraldo A S Passos
Dec 5, 2003·Current Biology : CB·Hartmut Scheel, Kay Hofmann
Oct 29, 2004·Nature Reviews. Cancer·Ann M Bode, Zigang Dong
Mar 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James W F CattoFreddie C Hamdy
Apr 14, 2005·Journal of Molecular Biology·Sabine WohlgemuthChristian Herrmann
May 4, 2005·Biochemical and Biophysical Research Communications·Matthias DobbelsteinGiovanni Blandino
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hideaki DotePhilip J Tofilon
Jul 5, 2005·Cancer Research·Eric E O'NeillWalter Kolch

❮ Previous
Next ❯

Citations

Mar 5, 2016·Journal of Ophthalmology·Maryam NajafiMohammad Arish
Jun 21, 2016·Genes·Emma FallahiDavid Matallanas
Mar 13, 2014·FEBS Letters·Natalia VolodkoShairaz Baksh
May 8, 2018·Cancers·Federica Lo SardoGiovanni Blandino
Aug 14, 2015·The Journal of Biological Chemistry·Jennifer LawShairaz Baksh
Oct 21, 2016·Journal of Cell Communication and Signaling·Mohammad Ayoub Rigi LadizDor Mohammad Kordi-Tamandani

❮ Previous
Next ❯

Methods Mentioned

BETA
deubiquitination

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

World Journal of Biological Chemistry
Valeriya Solozobova, Christine Blattner
Epigenetics : Official Journal of the DNA Methylation Society
Nicholas Underhill-DayF Latif
Free Radical Research
Consuelo BorrásJose Viña
© 2021 Meta ULC. All rights reserved