RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression.

Molecular Biology International
Dominic P Del Re, Junichi Sadoshima

Abstract

The RASSF proteins are a family of polypeptides, each containing a conserved Ras association domain, suggesting that these scaffold proteins may be effectors of activated Ras or Ras-related small GTPases. RASSF proteins are characterized by their ability to inhibit cell growth and proliferation while promoting cell death. RASSF1 isoform A is an established tumor suppressor and is frequently silenced in a variety of tumors and human cancer cell lines. However, our understanding of its function in terminally differentiated cell types, such as cardiac myocytes, is relatively nascent. Herein, we review the role of RASSF1A in cardiac physiology and disease and highlight signaling pathways that mediate its function.

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Citations

Mar 29, 2014·Genetic Testing and Molecular Biomarkers·Jin-Ge SiRu-Hong Chen
Jul 31, 2013·Progress in Biophysics and Molecular Biology·Chenyang DuanRuiyan Ma
Jun 15, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Dominic P Del Re
Feb 28, 2014·International Journal of Molecular Medicine·Lingjie Fu, Shulan Zhang
Jan 23, 2020·Cancers·Lucía García-GutiérrezDavid Matallanas

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Methods Mentioned

BETA
transgenic

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