Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation

Cytotherapy
Hangsoo KimShoichi Maruyama

Abstract

In patients receiving peritoneal dialysis, fungal or yeast peritonitis has a poor prognosis. In rat peritoneum with mechanical scraping, severe peritonitis can be induced by zymosan, a component of yeast (Zy/scraping peritonitis). Administration of rat adipose tissue-derived stromal cells (ASCs) potentially can improve several tissue injuries. The present study investigated whether rat ASCs could improve peritoneal inflammation in Zy/scraping peritonitis. Rat ASCs were injected intraperitoneally on a daily basis in rats with Zy/scraping peritonitis. Peritoneal inflammation accompanied by accumulation of inflammatory cells and complement deposition was suppressed by day 5 after injection of rat ASCs. The peritoneal mesothelial layer in Zy/scraping peritonitis with rat ASC treatment was restored compared with the peritoneal mesothelial layer without rat ASC treatment. Injected rat ASCs co-existed with mesothelial cells in the sub-peritoneal layer. In vitro assays showed increased cellular proliferation of rat mesothelial cells combined with rat ASCs by co-culture assays, confirming that fluid factors from rat ASCs might play some role in facilitating the recovery of rat mesothelial cells. Hepatocyte growth factor was released fro...Continue Reading

References

Aug 14, 1999·Immunology·O B SpillerB P Morgan
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A Y WangS F Lui
Sep 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hideki KawanishiTakao Shoji
Jan 25, 2005·Nephron. Experimental Nephrology·Koki MatsuoAkihisa Kanamaru
Feb 16, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ajay GuptaDavid Talbot
Mar 21, 2008·American Journal of Physiology. Renal Physiology·Hayato NishimuraSeiichi Matsuo
Dec 6, 2008·Stem Cells and Development·Shigejiro IwashimaSeiichi Matsuo
Jan 1, 2008·Organogenesis·Andrew J RosenbaumJoshua S Dines
Feb 19, 2010·Stem Cells and Development·Zhidan TuFeng Lin
Jun 22, 2011·Clinical and Experimental Nephrology·Masashi MizunoSeiichi Matsuo
Jun 29, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Tatsuhito WatanabeMomokazu Gotoh
Jul 19, 2011·Stem Cell Research·Stella Maris AlbarenqueAndrea Mohr
Jan 19, 2012·Anatomy & Cell Biology·Jeanne Adiwinata Pawitan
Jan 25, 2012·Pharmacology & Therapeutics·Naama Zeevi-LevinOfer Binah
Feb 4, 2012·Journal of the American Society of Nephrology : JASN·Arsh K JainAmit X Garg
Mar 23, 2012·JAMA : the Journal of the American Medical Association·Jianming TanCamillo Ricordi
Jul 17, 2012·Biologicals : Journal of the International Association of Biological Standardization·Patricia Gálvez MartínBeatriz Clares Naveros
Sep 12, 2012·Cell Transplantation·Takayuki KatsunoShoichi Maruyama

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Masashi MizunoSeiichi Matsuo
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Li-ye YangGuo-zhen Hui
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Xi-ping ChenSheng-wei Li
© 2021 Meta ULC. All rights reserved