Rat and human Schwann cells in vitro can synthesize and express MHC molecules

Muscle & Nerve
Patricia J ArmatiP Gatenby

Abstract

The expression of MHC class I and II molecules on cultured rat and human Schwann cells (SCs) was studied to determine whether these molecules could be synthesized by SCs in the absence of T cells. Normal rat and human SCs in vitro expressed low levels of class I MHC, but this was markedly increased by incubation with interferon gamma (IFN-gamma). Untreated SCs of rat or human origin did not express detectable class II MHC molecules, but after 48 hours incubation with IFN-gamma 100 U/ml, 20% of rat SCs and 90% of human SCs were class II positive. Immunoelectron microscopy confirmed the surface expression of MHC molecules on SCs and demonstrated class II MHC within endocytotic vesicles. These findings provide further evidence for an immunological role for SCs as antigen presenting cells or as targets for cytotoxic T cells.

References

Mar 13, 1987·Science·P Marrack
Aug 1, 1987·Immunological Reviews·P M AllenE R Unanue
Jun 13, 1988·Journal of Immunological Methods·P J ArmatiL Van der Lubbe
Apr 1, 1987·Annals of Neurology·J D PollardJ G McLeod
Oct 31, 1983·Neuroscience Letters·M R HirschC Goridis
Aug 23, 1984·Nature·G H WongJ W Schrader
Dec 1, 1963·Journal of Ultrastructure Research·E J NATHANIEL, D C PEASE
Jan 1, 1987·Immunology Today·P M Allen

❮ Previous
Next ❯

Citations

Feb 1, 1995·Muscle & Nerve·H P HartungK V Toyka
Jan 1, 1996·Springer Seminars in Immunopathology·H P HartungG Giegerich
Dec 14, 2004·Journal of Neurology·Jorge Correale, Andrés Villa
Aug 1, 1990·Journal of Neuroscience Methods·P J ArmatiF Llewellyn
May 1, 1995·Journal of Neuroscience Methods·O Lilje, P J Armati
Jun 1, 1994·Progress in Neurobiology·P J EvansS E Mackinnon
Apr 15, 1999·Journal of the Neurological Sciences·A L ConstableH P Hartung
Mar 10, 2001·Progress in Neurobiology·R KieferH P Hartung
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hannah V SiddleJim Kaufman
Jan 1, 1996·Plastic and Reconstructive Surgery·S R StrasbergJ B Hay
Apr 1, 1993·Acta Neurologica Scandinavica·A EngelhardtB Neundörfer
Sep 30, 1999·Environmental Health Perspectives·H A El-FawalM Y Shamy
Apr 18, 2014·Journal of Clinical Immunology·Nevena TzekovaPatrick Küry
Apr 1, 2014·Journal of Neuroinflammation·Mark StettnerBernd C Kieseier
Jun 3, 2014·BMC Musculoskeletal Disorders·Lihong FanKunzheng Wang
Jul 1, 1997·Journal of Neuroimmunology·O Lilje, P J Armati
Sep 14, 2006·Current Opinion in Neurology·Bernd C KieseierHeinz Wiendl
Sep 8, 2007·Muscle & Nerve·Gerd Meyer zu HörsteBernd C Kieseier
Jan 28, 1994·Brain Research·A L ConstableH P Hartung
Jan 20, 1992·Brain Research·D BianchiniG L Mancardi
Dec 22, 1999·Experimental and Molecular Pathology·O Lilje, P J Armati
Feb 21, 2013·Journal of the Neurological Sciences·Patricia J Armati, Emily K Mathey
Apr 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·A Baron-Van EvercoorenR Liblau
Nov 5, 2019·Cancer Immunology, Immunotherapy : CII·Sophia H ZhangYuri L Bunimovich
Nov 1, 1996·Multiple Sclerosis : Clinical and Laboratory Research·R P Lisak
Apr 29, 1999·Brain Pathology·R GoldH P Hartung
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin S ImSteven A Porcelli
Jul 12, 2017·Immunogenetics·Alison Caldwell, Hannah V Siddle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.