PMID: 19912892Dec 1, 1992Paper

Rat anterior pituitary estrogen receptor mRNA levels after estrogen and progesterone treatment

Molecular and Cellular Neurosciences
L ChorichV B Maheshi

Abstract

Previous work from our laboratory has demonstrated that progesterone can induce a rapid decrease in estrogen receptor (ER) binding in the anterior pituitary of the rat. This effect of progesterone on ER correlates well with the loss of estrogen action. The objectives of this study were to determine whether the rapid decrease in ER binding in the rat pituitary after a single injection of estradiol and the decrease in ER binding induced by progesterone in the estrogen-primed rat could be due to a suppression of mRNA levels for the estrogen receptor. Ovariectomy for 14 days decreased ER mRNA levels and injection of 2 mug of estradiol in ethanol:saline for 3 days increased ER mRNA levels. A single injection of 1 mug of estradiol brought about no change in ER mRNA levels in the pituitary of ovariectomized rats within 1 h of administration. Five micrograms of estradiol increased the ER mRNA levels, whereas 10 mug of estradiol brought about a decrease in ER mRNA levels. Thus, the reported decrease in pituitary ER binding after 1 and 5 mug of estradiol was not accompanied by a similar change in ER mRNA levels, suggesting that the decrease in ER binding may be due to accelerated processing of ER or to decreased translation of ER mRNA. W...Continue Reading

References

Mar 1, 1978·Biology of Reproduction·J A Cidlowski, T G Muldoon
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·V B Mahesh, D W Brann
Apr 1, 1989·Molecular Endocrinology·M A ShupnikW W Chin
Mar 25, 1987·Nucleic Acids Research·S KoikeM Muramatsu
Aug 1, 1988·Developmental Biology·N ShimizuR Zak
Mar 1, 1985·Neuroendocrinology·J C Peduto, V B Mahesh
Feb 15, 1981·The Biochemical Journal·F AuricchioA Rotondi
Dec 14, 1984·Biochemical and Biophysical Research Communications·E J SmanikT G Muldoon
Jan 1, 1983·Molecular and Cellular Biochemistry·J A Kassis, J Gorski
May 14, 1982·Biochemical and Biophysical Research Communications·F AuricchioA Rotondi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.