PMID: 2113417May 7, 1990Paper

Rat astrocytes express interferon-gamma immunoreactivity in normal optic nerve and after nerve transection

Brain Research
B SchmidtH P Hartung

Abstract

Astrocytes are pivotal components of immune reactions in the CNS. We further support this notion by the localization of the lymphokine interferon-gamma (IFN-gamma), which plays an important role during immune responses, to astrocytes in rat optic nerve (ON). Astrocytes identified by glial fibrillary acidic protein immunoreactivity were IFN-gamma positive in normal and transected ON while oligodendrocytes did not express IFN-gamma immunoreactivity. These findings indicate that astrocytes can generate important signals which orchestrate immunoinflammatory responses in the brain.

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Citations

Sep 5, 2002·Journal of Neuroscience Research·Sonia FranciosiJames G McLarnon
May 26, 1998·Journal of the Neurological Sciences·B G Xiao, H Link
Oct 2, 2001·Neurochemistry International·E N BenvenisteG M O'Keefe
Jan 26, 1999·Cytokine & Growth Factor Reviews·E N Benveniste
Jan 5, 2000·Journal of Neurochemistry·K TakahashiS Shibahara
Dec 20, 2011·The International Journal of Neuroscience·Wanida Tripanichkul, Em-orn Jaroensuppaperch
Sep 28, 2004·Brain Pathology·Rebecca D FolkerthHannah C Kinney

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