Rat brain binds adrenal steroid hormone: radioautography of hippocampus with corticosterone

J Gerlach, Bruce S McEwen


Tritiated corticosterone injected subcutaneously into adrenalectomized male rats 1 hour before killing produced intense labeling of the hippocampus in radioautograms prepared by a method that reduced or prevented diffusion of the radioactive material. The pyramidal neurons of the cornu ammonis and the granule neurons of the gyrus dentatus contained more radioactivity than did other regions of the brain; however, the intensity of labeling varied among adjacent neurons. The nuclei of many neurons were clearly labeled but radioactivity was relatively sparse in the cytoplasm, in the axons where they branch from cell bodies, and in adjacent neuropil.


Jan 1, 1975·Developmental Psychobiology·D S OltonE Howard
Apr 1, 1993·Hippocampus·C PavlidesBruce S McEwen
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Jan 1, 1986·Agents and Actions·M KoltaiL Szekeres
Jan 15, 1992·Biological Psychiatry·Bruce S McEwenR Spencer
Jul 27, 1973·Brain Research·Bruce S McEwen, G Wallach
Jul 25, 1983·Brain Research·R M SapolskyT C Rainbow
Feb 28, 1989·European Journal of Pharmacology·J D MillerC A Fuller
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Nov 1, 1990·Behavioral and Neural Biology·E J RoyC W Bemm
Dec 1, 1985·Brain Research·M J MeaneyBruce S McEwen
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Jan 1, 1978·Psychoneuroendocrinology·A VernadakisR Nidess
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