PMID: 8946052Nov 22, 1996Paper

Rat cerebral mast cells undergo phenotypic changes during development

Brain Research. Developmental Brain Research
V DimitriadouM Garbarg

Abstract

The evolution of rat cerebral mast cell phenotype during development was studied using antibodies against the granule chymases, rat mast cell protease I (RMCP-I) and rat mast cell protease II (RMCP-II) and their gene transcripts, as markers for serosal and mucosal mast cells, respectively. In situ hybridization using specific oligoprobes for RMCP-II permitted visualization of RMCP-II mRNA-containing cells as early as day 15 of embryonic development (E15). From E19 to day 4 postpartum (D4) their number increased whilst they migrated from the pia mater to the choroid fissure; at D8 cells expressing RMCP-II gene transcripts were no longer observed. The 3'-end untranslated nucleotide sequence of the RMCP-I cDNA was established in order to design selective cDNA probes for Northern blot analysis of both enzymes. Northern blot analysis revealed a strong expression of RMCP-I and RMCP-II mRNAs at D2. At D4, RMCP-I mRNA expression was still high, whereas that of RMCP-II was decreased. In adult brain, mRNA expression for both proteases was low, but detectable. Quantification of both proteases by ELISA showed that, from E19 to D4, levels of RMCP-II were maximal at E19 and remained constant until D4, whereas RMCP-I increased as a function o...Continue Reading

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Citations

Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
Nov 30, 2002·Journal of Neuroimmunology·Jacques P ZappullaRoland S Liblau
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Sep 4, 2007·Brain Research·Mona KhalilAnn-Judith Silverman
Sep 8, 2007·Journal of Anatomy·Helen MichaloudiGeorgios C Papadopoulos
Jan 15, 2005·Neurobiology of Disease·Bettina MesplèsPierre Gressens
Jul 16, 2008·Brain Research·Helen MichaloudiGeorgios C Papadopoulos
Oct 19, 2016·Journal of Neuroscience Research·Raffaella MorettiBobbi Fleiss
Aug 15, 2021·Acta Neuropathologica Communications·Mariángeles KovacsEmiliano Trias

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