Rat cytosolic epoxide hydrolase

Advances in Experimental Medicine and Biology
F OeschW Wörner

Abstract

Rat liver microsomal and cytosolic epoxide hydrolase may be distinguished through differences in substrate specificity: styrene 7,8-oxide is preferentially hydrolyzed by the microsomal form, while trans-stilbene oxide is the preferred substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of Sprague-Dawley (outbred strain) liver cytosolic epoxide hydrolase were observed, varying from 2 to 77 pmol/min X mg protein. Interindividual variations were much lower for microsomal epoxide hydrolase. The specific activity of Fischer F-344 (inbred strain) liver cytosolic epoxide hydrolase varied only by a factor of 2. The specific activity of cytosolic epoxide hydrolase using trans-stilbene oxide as the substrate was highest in kidney and heart, followed by liver, brain, lung, testis, and spleen. For microsomal epoxide hydrolase, the specific activity was much lower in extrahepatic tissues than in liver. None of the commonly used inducers of xenobiotic metabolizing enzymes caused significant changes in rat liver cytosolic epoxide hydrolase. However, peroxisome proliferating drugs were found to drastically increase cytosolic epoxide hydrolase activity. Treatment for one week with a diet contain...Continue Reading

Citations

Apr 3, 2009·Archives of Toxicology·Martina DeckerAnnette Cronin
Oct 2, 2009·Nature Reviews. Drug Discovery·John D Imig, Bruce D Hammock
May 4, 2010·Cardiovascular Therapeutics·Hong QiuNipavan Chiamvimonvat
Sep 12, 2006·Cardiovascular Drug Reviews·John D Imig
Mar 6, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Priyanka SuraDavid F Grant
Apr 23, 2013·Drug Metabolism Reviews·Abdulaziz M S AlsaadAyman O S El-Kadi
Jan 13, 2001·Chemico-biological Interactions·A J Fretland, C J Omiecinski
Jun 28, 2011·International Journal of Cardiology·Ting-Ting ZhaoShui-Ping Zhao
Mar 8, 2005·Progress in Lipid Research·John W NewmanBruce D Hammock
Dec 15, 2007·Biochimica Et Biophysica Acta·Hiromasa TanakaBruce D Hammock

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