PMID: 7546153Jan 1, 1995Paper

Rat heart-aorta cluster transplantation: a novel model to study transplant rejection

Transplant International : Official Journal of the European Society for Organ Transplantation
M D'SilvaP McMaster

Abstract

The purpose of this study was to develop a microsurgical cluster model of heart plus entire thoracic aorta transplantation and to compare it to the isolated model of heart transplantation as a tool to study transplant rejection. Thirty-six syngeneic (DA x DA and Lew x Lew) and allogeneic (DA x PVG and DA x Lew) cluster heart-aorta transplants were compared to 43 syngeneic and allogeneic isolated heart grafts. Graft survival, recipient survival and histological data on myocardial and aortic tissues were assessed. There was no statistically significant difference in graft survival between the two models studied (P > 0.05). In the cluster transplants, the aortic component was spared the severity of acute rejection noted for the myocardial counterpart. In conclusion, the results demonstrated that the cluster model was technically feasible and highly reproducible. Additionally, it was possible to apply this model to the study of experimental allograft rejection using novel immunosuppressants. The success of the cluster model in strongly mismatched transplant strain combinations underscores its potential for application in slower rejection combinations, making it particularly suited for chronic rejection studies. The inherent capacit...Continue Reading

References

Jun 1, 1992·The Annals of Thoracic Surgery·J A St CyrD R Clarke
Mar 1, 1992·Journal of Cardiac Surgery·F M LupinettiK C Moore
Feb 1, 1992·Transplantation·P S AlmondD L Dunn
Oct 1, 1991·The Annals of Thoracic Surgery·D Schuch, L Wolff
Apr 1, 1990·Transplantation·H el Khatib, F M Lupinetti

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