Rat hippocampal mossy fibers contain cholecystokinin-like immunoreactivity

The Anatomical Record
J ChandyT A Milner

Abstract

The possibility that mossy fiber endings in the rat hippocampal formation may contain cholecystokinin (CCK) was reexamined. For this, CCK-immunoreactivity was examined by light and electron microscopy using the avidin-biotin complex method. At the light level, the topographical distribution of perikarya and processes with CCK-like immunoreactivity (CCK-LI) was similar to that previously described by others. Ultrastructural analysis of the dentate gyrus and CA3 region of the hippocampus revealed that some mossy fiber terminals contained CCK-LI most often affiliated with large, dense-core vesicles (DCV). Quantitative analysis revealed that 4-8% of the mossy terminal profiles examined (n = 350) contained CCK-labeled DCVs, which corresponded to 0.03-0.2 labeled DCVs per 100 microns2 of neuropil. The presence of CCK-LI within mossy fibers in the rat suggests that there is less species variability in peptide expression in this pathway than formerly believed.

References

Feb 8, 1991·The Journal of Comparative Neurology·S N Schiffmann, J J Vanderhaeghen
Sep 1, 1980·Clinics in Gastroenterology·J F Rehfeld
Dec 10, 1981·The Journal of Comparative Neurology·R S GreenwoodJ N Hayward

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