PMID: 8964912May 1, 1996Paper

Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies

Journal of Neuroimmunology
C LiuE B De Souza

Abstract

A protein which facilitates the binding between interleukin-1 (IL-1) and the type I IL-1 receptor (designated as interleukin-1 receptor accessory protein, IL-1RAcP) has recently been cloned in mouse cells. In the present study, a rat homolog of the mouse IL-1RAcP was isolated from a rat superior cervical ganglion library. The deduced 570 amino acid sequences between rat and mouse IL-1RAcP have > 95% sequence identity to each other with similar predicted signal peptide sequence (20 amino acids), extracellular domain (339 amino acids), a single transmembrane domain (24 amino acids) and a long intracellular domain (187 amino acids). The rat IL-1RAcP has approximately 25% sequence identity to the rat type I IL-1 receptor and a predicted extracellular domain with three immunoglobulin-like loops. RNase protection assays demonstrated that rat IL-1RAcP is expressed in both brain and peripheral tissues with the highest densities present in liver and brain areas such as hypothalamus, cerebral cortex, hippocampus and cerebellum; significantly lower densities were present in lung and in immune tissues such as thymus and spleen. The presence of IL-1RAcP in brain was confirmed by in situ hybridization histochemical studies with a discrete lo...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Oct 1, 1990·Experimental Neurology·A M Fagan, F H Gage
Nov 1, 1990·Journal of Neuroscience Research·W J FriedmanH Persson
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R ChizzoniteU Gubler
Oct 14, 1988·Biochemical and Biophysical Research Communications·G KatsuuraA Arimura
Nov 1, 1988·Pediatric Research·W Strober, S P James
Oct 22, 1987·The Journal of Comparative Neurology·M RickmannW M Cowan
Apr 15, 1983·Cellular Immunology·B KleinB Serrou
Jul 14, 1995·The Journal of Biological Chemistry·G E CrostonD V Goeddel
Jun 9, 1995·The Journal of Biological Chemistry·S A GreenfederG Ju
Nov 1, 1994·Brain Research. Molecular Brain Research·K YabuuchiM Satoh
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SimsK Shanebeck
May 17, 2005·Journal of Thrombosis and Haemostasis : JTH·W Bode
Feb 1, 1986·Immunology Today·J J OppenheimS K Durum

❮ Previous
Next ❯

Citations

Apr 6, 2004·Developmental and Comparative Immunology·Sumathi SubramaniamCharles Cunningham
Nov 1, 1996·Journal of Neuroimmunology·T W LovenbergR A Maki
Jan 4, 2001·Trends in Neurosciences·N J Rothwell, G N Luheshi
Jun 25, 1999·Brain Research. Molecular Brain Research·D GayleC R Plata-Salamán
Nov 8, 2002·Journal of Neurochemistry·Emmanuel PinteauxGiamal N Luheshi
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P TaishiJ M Krueger
Aug 14, 1997·Annals of the New York Academy of Sciences·K W KelleyR Dantzer
Mar 26, 2014·Neurotoxicology·Barbara VivianiMarina Marinovich
Dec 10, 1998·Journal of Neuroimmunology·Y Bai, R P Hart
Nov 5, 2003·Journal of Neuroimmunology·Fiona M RossAlexej Verkhratsky
Aug 1, 2006·Neurologic Clinics·Robert Dantzer
Mar 5, 2008·Journal of Neurochemistry·Birgit Fogal, Sandra J Hewett
Apr 25, 2009·Immunology and Allergy Clinics of North America·Robert Dantzer
Mar 17, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sophie Layé
Feb 28, 2003·Science's STKE : Signal Transduction Knowledge Environment·Aisling Dunne, Luke A J O'Neill
Sep 27, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J Licinio, P Frost
Aug 23, 1996·The Journal of Biological Chemistry·C LiuE B De Souza
Jun 25, 1998·The American Journal of Physiology·M K HansenJ M Krueger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.