PMID: 9420647Mar 1, 1995Paper

Rat infarct model of myocardial infarction and heart failure

Journal of Cardiac Failure
S Goldman, T E Raya

Abstract

This review outlines the development and current use of the rat coronary artery ligation model of heart failure. The techniques to ligate the left coronary artery and to obtain morphologic/hemodynamic measurements are described. The authors show how the pathology seen in this model relates to clinical ischemic heart disease. An effort is made throughout the review to relate the changes that occur in this model to clinically relevant observations. For example, the progression to heart failure in these rats is similar to what happens when a patient sustains a large myocardial infarction, survives, but goes on to develop heart failure without another ischemic insult. In both rats and people with large infarctions, the noninfarcted myocardium, even though not damaged at the time of the infarct, cannot compensate sufficiently to prevent the eventual development of heart failure. In addition to being a good approximation of human disease, the responses to pharmacologic interventions, like angiotensin converting enzyme inhibitors, in rats has proved useful in predicting what will happen in humans given the same treatment. More recent data on the molecular control of ventricular remodeling emphasizes how this model will provide importa...Continue Reading

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Citations

Apr 6, 2001·Alcoholism, Clinical and Experimental Research·S D KimM R Piano
Mar 5, 2011·Journal of Visualized Experiments : JoVE·Yewen WuBradley K McConnell
May 15, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abhro Jyoti Roy, P Stanely Mainzen Prince
Mar 1, 1997·Journal of Cardiac Failure·A M DuncanD J Campbell
Oct 16, 2007·Biochemical Pharmacology·James J LeyMyron D Ginsberg
Nov 14, 2019·The Journal of Physiology·Erin L O'CallaghanJulian F R Paton
May 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joan Smith SonnebornPaul Thomas
Mar 1, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Suree LekawanvijitHenry Krum
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H Yoshida, M Karmazyn
Oct 4, 2000·Physiological Genomics·D LynN L Emmett
Jan 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maximilian I PinkhamCarolyn J Barrett
Nov 13, 2021·Clinical and Experimental Pharmacology & Physiology·Marwa MedhetEbtehal El-Demerdash

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