Rat liver DNA damage by the non-hepatocarcinogen 3,2'-dimethyl-4-aminobiphenyl

Cancer Letters
A L HellemannG M Williams

Abstract

The intestinal carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMAB) and the hepatocarcinogen N-2-acetylaminofluorene (AAF) were administered intraperitoneally to male F344 rats to determine if both would produce DNA damage in the liver. Hepatocyte primary cultures (HPC) were prepared and DNA-repair was assessed in vitro by autoradiography. Hepatocytes from both DMAB- and AAF-exposed rats displayed DNA repair synthesis. These results confirm other observations that non-hepatocarcinogens can produce DNA damage in the liver, and that they can be detected in both in vitro and in vivo HPC/DNA repair assays.

Citations

Oct 1, 1987·Mutation Research·B E ButterworthG Williams
Nov 1, 1991·Toxicology and Applied Pharmacology·C A McQueenG M Williams

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