Apr 1, 1976

Rat-liver superoxide dismutase. Purification and age-related modifications

European Journal of Biochemistry
U Reiss, D Gershon

Abstract

Cytoplasmic superoxide dismutase has been purified from livers of young (6 months) and old (27 months) rats. The enzyme purified from old animals shows an age-related reduction in the specific activity, accumulation of antigenically cross-reacting material and increased sensitivity to temperature. No differences were found in the molecular weight, electrophoretic mobility, antigenicity and Ki between enzymes purified from young and old rats. This is the first demonstration of age-related alterations in a purified form of a non-metabolic enzyme, which can be related to reduced activity. The possible role of this reduced activity in age-dependent deterioration of cellular functions is discussed.

  • References22
  • Citations90

Mentioned in this Paper

Metabolic Process, Cellular
Precipitin Tests
Enzymes, antithrombotic
Hypokinesia
Cross Reactions
Senility
Cytoplasmic
Enzymes for Treatment of Wounds and Ulcers
Purification Aspects
Ag-Zn Superoxide Dismutase

About this Paper

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