PMID: 6978288Mar 1, 1982Paper

Rat major histocompatibility RT1.C antigens of restricted tissue distribution consist of two polypeptide chains with molecular weights of about 42 000 and 12 500

Immunogenetics
D HausteinE Günther

Abstract

The RT1.C region has recently been defined genetically as a third region of the rat major histocompatibility system, RT1, and has been shown to code for cell-surface antigens with restricted tissue distribution (present on lymphocytes and absent from red blood cells and liver) and for target antigens of unrestricted cytotoxic T lymphocytes. Immunoprecipitation with C-antigen-specific alloantisera and SDS-PAGE analysis, reveal that C-region products are glycoproteins composed of molecules of 40 500-43 000 and 12 500 molecular weight, respectively. Thus, the RT1.B region, which codes for class II molecules, is flanked by RT1 regions which determine class I molecules (as defined biochemically), which are either expressed ubiquitously (RT1.A antigens) or in a restricted manner (RT1.C products). The homology to H-2Qa antigens is discussed.

References

Mar 24, 1977·Nature·G W Butcher, J C Howard
Jan 1, 1981·Immunogenetics·J MichaelsonH Yudkowitz
May 1, 1981·The Journal of Experimental Medicine·M J SoloskiE S Vitetta
Apr 1, 1980·European Journal of Immunology·K F Lindahl, B Hausmann
Aug 1, 1980·European Journal of Immunology·D Haustein, E Günther
Jan 1, 1980·Immunogenetics·T H Stanton, L Hood

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Citations

Jan 1, 1987·Immunogenetics·D N MisraT J Gill
Jan 1, 1984·Immunogenetics·A B BegovichD L Gasser
Jan 1, 1987·Immunogenetics·D N MisraT J Gill
Jan 1, 1989·Immunogenetics·H W KunzT J Gill
Nov 15, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gordon D WuDonald V Cramer
Aug 1, 1997·American Journal of Reproductive Immunology : AJRI·D A Clark
Oct 1, 1984·Journal of Immunogenetics·R A HarrisI F McKenzie
Aug 1, 1983·Journal of Immunogenetics·T J GillD N Misra

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