Rat mandibular distraction osteogenesis: latency, rate, and rhythm determine the adaptive response

The Journal of Craniofacial Surgery
M F PaccioneMichael T Longaker

Abstract

Distraction osteogenesis is a well-established technique of endogenous tissue engineering. The biomechanical factors thought to affect the quality of the distraction regenerate include the latency, rate, rhythm, and consolidation period. In an effort to understand the impact of these parameters on regenerate bone formation, this study was designed to decipher the most adaptive response in a rat model of mandibular distraction osteogenesis. Ninety-six adult Sprague-Dawley rats were divided into 16 subgroups (n = 6 per subgroup) based on variations in the distraction parameters (i.e., latency, rate, and rhythm). After a 28-day consolidation period, the mandibles were harvested, decalcified, and sectioned. A standardized histologic ranking system was used to evaluate the effect of each protocol on the adaptive response of the regenerate bone. In this study, we have demonstrated that the latency period dramatically affects the success of distraction osteogenesis. Furthermore, distraction rates up to 0.50 mm per day stimulated excellent regenerate bone formation, whereas greater distraction rates produced a fibrous union. Finally, higher frequency distraction (i.e., increased rhythm) appeared to accelerate regenerate bone formation....Continue Reading

References

Oct 1, 1992·Acta Orthopaedica Scandinavica·O Grundnes, O Reikerås
Jul 1, 1992·Annals of Plastic Surgery·N S KarpC H Thorne
May 1, 1990·The Journal of Bone and Joint Surgery. British Volume·S H White, J Kenwright
May 1, 1973·Plastic and Reconstructive Surgery·C C SnyderE Z Browne
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z AranyD M Livingston
Sep 18, 1997·Plastic and Reconstructive Surgery·F Ortiz MonasterioJ Sainz Arregui
Oct 20, 1998·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·K TavakoliM D Poole
Nov 12, 1998·Plastic and Reconstructive Surgery·N M RoweM T Longaker
Jan 26, 1999·Clinical Orthopaedics and Related Research·J Glowacki
Jan 26, 1999·Clinical Orthopaedics and Related Research·R N RosierD G Hicks
May 26, 1999·Annals of Plastic Surgery·N M RoweM T Longaker

❮ Previous
Next ❯

Citations

Jul 30, 2009·Odontology·Lisa R AmirAntonius L J J Bronckers
Sep 5, 2007·Annals of Biomedical Engineering·A BoccaccioD J Kelly
Jul 27, 2011·Plastic and Reconstructive Surgery·Edward H DavidsonStephen M Warren
May 27, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Atsushi KimuraKen Omura
Feb 24, 2004·Medical & Biological Engineering & Computing·M MullenderJ Klein-Nulend
Feb 7, 2004·Acta Orthopaedica Scandinavica·Hiroshi MizutaKatsumasa Takagi
Aug 22, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sevin OzgülAydin Sav
Nov 19, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Xi Ling LiuLi Wu Zheng
Jul 29, 2011·Revue de stomatologie et de chirurgie maxillo-faciale·T SchoumanG Dubois
Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Li Wu ZhengLim Kwong Cheung
May 12, 2009·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Li Wu ZhengLim Kwong Cheung
Feb 5, 2004·International Journal of Oral and Maxillofacial Surgery·H TerheydenD C Rueger
Mar 4, 2008·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Franz-Josef KramerHannes Schierle
Mar 25, 2008·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Urville Mardijanto DjasimKarel George Hendrik Van Der Wal
Oct 24, 2007·The Journal of Surgical Research·Kirit A BhattGeoffrey C Gurtner
Jul 10, 2007·International Journal of Oral and Maxillofacial Surgery·U M DjasimK G H van der Wal
Apr 24, 2007·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Wei-Qiao ZhuZhi-Ying Wang
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tony D FangMichael T Longaker
May 11, 2011·Clinical Implant Dentistry and Related Research·Nikola SaulacicDieter D Bosshardt
Mar 8, 2005·The British Journal of Oral & Maxillofacial Surgery·A R F HasseC E Zimmermann
Sep 20, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Uk-Kyu KimChing-Chang Ko
Jun 4, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nikola SaulacicPaolo Scolozzi
Aug 12, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Ginger C SlackJames P Bradley
Jul 10, 2002·International Journal of Oral and Maxillofacial Surgery·G SwennenH Schliephake
Mar 26, 2003·International Journal of Oral and Maxillofacial Surgery·T AidaJ Fukuda
Sep 4, 2004·The Journal of Craniofacial Surgery·Hong-Zhi ZhouLiang Ma
Jun 24, 2004·The Journal of Craniofacial Surgery·Franz-Josef KramerHannes Schierle
Sep 7, 2018·Plastic and Reconstructive Surgery·Jiriys G GininiAdi Rachmiel
Mar 19, 2011·The Journal of Craniofacial Surgery·Hyun-Seung MoonJung-Yul Cha
Oct 4, 2007·The Journal of Craniofacial Surgery·Nond RojvachiranondaCharan Mahatumarat
Aug 4, 2005·The Journal of Craniofacial Surgery·Muhitdin EskiAyhan Ozcan
Feb 8, 2006·Plastic and Reconstructive Surgery·Morad AskariJames P Bradley
Nov 27, 2014·Plastic and Reconstructive Surgery. Global Open·Adi RachmielDror Aizenbud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.