PMID: 9441716Jan 27, 1998Paper

Rat olfactory mucosa displays a high activity in metabolizing methyl tert-butyl ether and other gasoline ethers

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J Y HongW Q Huang

Abstract

Methyl tert-butyl ether (MTBE) is a widely used gasoline oxygenate. Two other ethers, ethyl tert-butyl ether (ETBE) and tert-amyl methyl ether (TAME), are also used in reformulated gasoline. Inhalation is a major route for human exposure to MTBE and other gasoline ethers. The possible adverse effects of MTBE in humans are a public concern and some of the reported symptoms attributed to MTBE exposure appear to be related to olfactory sensation. In the present study, we have demonstrated that the olfactory mucosa of the male Sprague-Dawley rat possesses the highest microsomal activities, among the tissues examined, in metabolizing MTBE, ETBE, and TAME. The metabolic activity of the olfactory mucosa was 46-fold higher than that of the liver in metabolizing MTBE, and 37- and 25-fold higher, respectively, in metabolizing ETBE and TAME. No detectable activities were found in the microsomes prepared from the lungs, kidneys, and olfactory bulbs of the brain. The observations that the metabolic activity was localized exclusively in the microsomal fraction, depended on the presence of NADPH, and was inhibitable by carbon monoxide are consistent with our recent report on MTBE metabolism in human and mouse livers (Hong et al., 1997) and fu...Continue Reading

Citations

Sep 15, 2011·Biodegradation·Mojtaba ShamsipurShahram Abolhassan Tash
Oct 31, 2001·Toxicology Letters·W DekantA Amberg
Jan 13, 2016·Analytical and Bioanalytical Chemistry·Rachel SchoumackerJean-Luc Le Quéré
Sep 6, 2015·Toxicology and Applied Pharmacology·Keith D SalazarWeihsueh A Chiu
May 31, 2003·Journal of Toxicology and Environmental Health. Part a·Janet M BensonEdward B Barr
Oct 9, 2015·Chemical Senses·Philippe FaureJean-Marie Heydel
Apr 25, 2007·Critical Reviews in Toxicology·Douglas McGregor
Jul 1, 2006·Critical Reviews in Toxicology·Douglas McGregor
Sep 29, 2015·Critical Reviews in Toxicology·Kenneth T Bogen, Jacqueline M Heilman

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