Apr 24, 1990

Rat pancreastatin inhibits both pancreatic exocrine and endocrine secretions in rats

Regulatory Peptides
K MiyasakaN Fujii

Abstract

Effects of synthetic rat pancreastatin C-terminal fragment on both exocrine and endocrine pancreatic functions were examined in rats, in vivo and in vitro. Pancreastatin (20, 100 pmol, 1 nmol/kg/h) significantly inhibited CCK-8-stimulated pancreatic juice flow and protein output in a dose-related manner, in vivo. The inhibitory effect on bicarbonate output was not statistically significant. Pancreastatin did not significantly inhibit basal pancreatic secretions in vivo, and did not inhibit amylase release from the dispersed acini, in vitro. Insulin release stimulated by intragastric administration of glucose (5 g/kg) was significantly inhibited by pancreastatin (1 nmol/kg/h), in vivo. Plasma glucose concentrations were increased by pancreastatin infusion, but the increase was not statistically significant. Furthermore, pancreastatin inhibited insulin release from isolated islets, in vitro. Synthetic rat C-terminal pancreastatin fragment has bioactivities on both exocrine and endocrine pancreatic functions in rats.

Mentioned in this Paper

CHGA gene
Carboxy-Terminal Amino Acid
Pancreatic Secretion Function
August Rats
Glucose, (beta-D)-Isomer
Carbonic Acid Ions
Kinevac
Amylase Measurement
Pancreatic Juice
Endocrine System

About this Paper

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