PMID: 9525656Apr 3, 1998Paper

Rat parvovirus type 1: the prototype for a new rodent parvovirus serogroup

Journal of Virology
Lisa J Ball-GoodrichR O Jacoby

Abstract

A newly recognized parvovirus of laboratory rats, designated rat parvovirus type 1a (RPV-1a), was found to be antigenically distinct. It was cloned, sequenced, and compared with the University of Massachusetts strain of rat virus (RV-UMass) and other autonomous parvoviruses. RPV-1a VP1 identity with these viruses never exceeded 69%, thus explaining its antigenic divergence. In addition, RPV-1a had reduced amino acid identity in NS coding regions (82%), reflecting phylogenetic divergence from other rodent parvoviruses. RPV-1a infection in rats had a predilection for endothelium and lymphoid tissues as previously reported for RV. Infectious RPV-1a was isolated 3 weeks after inoculation of infant rats, suggesting that it, like RV, may result in persistent infection. In contrast to RV, RPV-1a was enterotropic, a characteristic previously associated with parvovirus infections of mice rather than rats. RPV-1a also differed from RV in that infection was nonpathogenic for infant rats under conditions where RV infection causes high morbidity and mortality. Thus, RPV-1a is the prototype virus of an antigenically, genetically, and biologically distinct rodent parvovirus serogroup.

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Citations

Mar 21, 2001·The Journal of General Virology·M Söderlund-VenermoD J Pintel
Feb 15, 2001·The Journal of General Virology·L J Ball-GoodrichR Jacoby
Jul 19, 2002·The Journal of General Virology·Cho-Hua WanLela K Riley
May 29, 2008·ILAR Journal·David G BesselsenLela K Riley
Nov 23, 2000·Journal of Virology·R O JacobyL Ball-Goodrich
May 13, 2006·The Journal of General Virology·David G BesselsenRobert S Livingston

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