PMID: 6538071Feb 1, 1984Paper

Rat renal 25-hydroxyvitamin D3 1- and 24-hydroxylases: their in vivo regulation

The American Journal of Physiology
Y Tanaka, H F Deluca

Abstract

The effects of thyroparathyroidectomy, parathyroid hormone, 1,25-dihydroxyvitamin D3, dietary calcium, dietary phosphorus, age, and sex on the renal 25-hydroxyvitamin D3 1- and 24-hydroxylases measured in vitro in rats have been studied. Thyroparathyroidectomy of vitamin D-deficient rats abolishes 25-hydroxyvitamin D3 1-hydroxylase activity, and administration of bovine parathyroid extract to the thyroparathyroidectomized rat restores diminished 1-hydroxylase activity. Both suppression and restoration of the enzyme activities require many hours (18-24 h) independent of rapid changes in serum calcium and inorganic phosphorus levels in response to these manipulations. Administration of 1,25-dihydroxyvitamin D3 to vitamin D-deficient rats suppresses 25-hydroxyvitamin D3 1-hydroxylase activity and stimulates 25-hydroxyvitamin D3 24-hydroxylase activity within 48 h. Rats maintained on a low-calcium or a low-phosphorus diet with a daily supplement of 20 IU vitamin D3 show high 25-hydroxyvitamin D3 1-hydroxylase activity and low 24-hydroxylase activity as compared with rats similarly treated but fed a diet containing adequate calcium or adequate phosphorus. When vitamin D-sufficient rats having suppressed renal 25-hydroxyvitamin D3 1-...Continue Reading

References

Jan 1, 1976·Annual Review of Biochemistry·H F DeLuca, H K Schnoes
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y TanakaH F DeLuca
Sep 1, 1970·The Journal of Nutrition·T SudaY Tanaka
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·I T BoyleH F DeLuca
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M GarabedianI T Boyle
Sep 1, 1972·The Journal of Clinical Investigation·H RasmussenD B Goodman
Feb 1, 1973·Endocrinology·Y TanakaH F DeLuca
Feb 1, 1973·Archives of Biochemistry and Biophysics·Y Tanaka, H F Deluca
Sep 18, 1973·Biochemical and Biophysical Research Communications·T SudaI Ezawa
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y Tanaka, H F DeLuca
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·O H SørensenA W Norman
Feb 2, 1980·British Medical Journal·D J BrownI MacIntyre

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Citations

Jun 16, 2019·Medicina·Guido GembilloDomenico Santoro
Nov 27, 2014·American Journal of Physiology. Endocrinology and Metabolism·Yongji WangHector F DeLuca
Mar 7, 2021·Medicina·Guido GembilloDomenico Santoro

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