Rat small intestine expresses the reelin-Disabled-1 signalling pathway

Experimental Physiology
Pablo García-MirandaA A Ilundain

Abstract

Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa. Intestinal reelin and Dab1 mRNA levels were maximal in the early stages of life, reaching adult levels in 1-month-old rats. Expression of reelin mRNA was restricted to fibroblasts, whereas mRNAs of Dab1, ApoER2, VldlR and integrins alpha3 and beta1 were observed in enterocytes, crypts and fibroblasts. Reelin protein was only observed in isolated intestinal fibroblasts and in a cell layer subjacent to the villus epithelium, which seems to be composed of myofibroblasts because it also reacted to alpha-smooth muscle actin. The Disabled-1 and VldlR protein signals were detected in the crypt and villus cells, and they were particularly abundant in the terminal web domain of the enterocytes. The ApoER2 protein signal was detected in the upper half of the villi but not in the crypts. This is the first report showing that rat intestinal mucosa expresses the reelin-Disabled-1 signalling system.

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Citations

Aug 18, 2012·Tissue Engineering. Part a·Pablo García-MirandaAnunciación A Ilundain
Jan 21, 2012·Current Opinion in Lipidology·Ryan E Temel, J Mark Brown
Dec 14, 2011·Journal of Physiology and Biochemistry·P García-MirandaA A Ilundáin
May 23, 2014·Molecular and Cellular Neurosciences·Martina BöttnerThilo Wedel
Nov 17, 2010·Journal of Cellular Biochemistry·María D Vázquez-CarreteroAnunciación A Ilundáin
Oct 15, 2013·Journal of Cellular Biochemistry·María D Vázquez-CarreteroAnunciación A Ilundain
Dec 10, 2013·Biology of the Cell·María D Vázquez-CarreteroAnunciación A Ilundain
Jul 20, 2016·Molecular Carcinogenesis·José Manuel Serrano-MoralesPablo García-Miranda
Oct 16, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elvira Khialeeva, Ellen M Carpenter
Nov 24, 2016·Journal of Bioenergetics and Biomembranes·María Dolores Vázquez-CarreteroMaría José Peral
Apr 14, 2016·Nature Communications·Esther CastellanoJulian Downward
Jul 26, 2016·Frontiers in Cellular Neuroscience·Hans H Bock, Petra May
Feb 13, 2021·International Journal of Molecular Sciences·Paula DlugoszJohannes Nimpf

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