Rat striatal adenosinergic modulation of ethanol-induced motor impairment: possible role of striatal cyclic AMP

Neuroscience
Z H MengM S Dar

Abstract

We have previously reported the involvement of the striatum in acute ethanol-induced motor incoordination and the striatal adenosinergic modulation of ethanol-induced motor incoordination through A1 receptor-mediated mechanism(s). The present study, a continuation of our previous work, was carried out to investigate the possible functional correlation between striatal cyclic AMP and ethanol-induced motor incoordination, and its modulation by striatal adenosine in Sprague-Dawley rats. Forskolin (0.1, 0.5 and 1.0 pmol), a known activator of adenylate cyclase, significantly attenuated ethanol-induced motor incoordination in a dose-dependent manner following its direct intrastriatal microinfusion. Forskolin also antagonized the accentuating effect of intrastriatal N6-cyclohexyladenosine on ethanol-induced motor incoordination. These results suggested that ethanol-induced motor incoordination might be functionally correlated to a decrease in the striatal cyclic AMP levels and that the striatal adenosine A1 receptors might modulate ethanol-induced motor incoordination through cyclic AMP signaling mechanism(s). Further support to this hypothesis was obtained by the actual measurement of the striatal cyclic AMP levels in the same exper...Continue Reading

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Citations

Nov 28, 2009·Pharmacology, Biochemistry, and Behavior·Joanna ListosSylwia Fidecka
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·Masami YoshimuraCristina E Gonzalez
Dec 21, 2017·Journal of Neurovirology·Jianlin HeSulie L Chang

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