Rat tibial osteotomy model providing a range of normal to impaired healing

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Joan D MilesLaurence E Dahners

Abstract

The purpose of this study was to develop an inexpensive and easily implemented rat tibial osteotomy model capable of producing a range of healing outcomes. A saw blade was used to create a transverse osteotomy of the tibia in 89 Sprague-Dawley rats. A 0.89 mm diameter stainless steel wire was then inserted as an intramedullary nail to stabilize the fracture. To impair healing, 1, 2, or 3 mm cylindrical polyetheretherketone (PEEK) spacer beads were threaded onto the wires, between the bone ends. Fracture healing was evaluated radiographically, biomechanically, and histologically at 5 weeks. Means were compared for statistical differences by one-way ANOVA and Holm-Sidak multiple comparison testing. The mean number of "cortices bridged" for the no spacer group was 3.4 (SD ± 0.8), which was significantly greater than in the 1 mm (2.3 ± 1.4), 2 mm (0.8 ± 0.7), and 3 mm (0.3 ± 0.4) groups (p < 0.003). Biomechanical results correlated with radiographic findings, with an ultimate torque of 172 ± 53, 137 ± 41, 90 ± 38, and 24 ± 23 N/mm with a 0, 1, 2, or 3 mm defect, respectively. In conclusion, we have demonstrated that this inexpensive, technically straightforward model can be used to create a range of outcomes from normal healing to ...Continue Reading

References

Jan 1, 1992·Bone·B Bak, K S Jensen
Jun 1, 1995·The Journal of Bone and Joint Surgery. American Volume·T A Einhorn
Jan 1, 1996·Lasers in Surgery and Medicine·R DavidM Soudry
Jun 26, 1999·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·F Gibson
Dec 25, 2002·Journal of Orthopaedic Trauma·Luise J HarrisonAllen E Goodship
Oct 28, 2004·Journal of Orthopaedic Trauma·Michaele B Manigrasso, J Patrick O'Connor
Mar 1, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sandra J ShefelbineAlexander Beck
Oct 9, 2007·Injury·Christopher Tzioupis, Peter V Giannoudis
Jun 13, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Katharina KasparGeorg N Duda
Oct 10, 2008·BMC Musculoskeletal Disorders·Christine KratzelBritt Wildemann

❮ Previous
Next ❯

Citations

Apr 11, 2014·Journal of Orthopaedics·Bikramjit S GrewalLaurence E Dahners
Jan 21, 2015·The Annals of Thoracic Surgery·Rikke F VestergaardJ Michael Hasenkam
Nov 6, 2012·Journal of Magnetic Resonance Imaging : JMRI·May A TahaJeff F Dunn
Jun 1, 2017·3D Printing and Additive Manufacturing·David S RuppertPaul S Weinhold

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Bettina WillieLutz Claes
© 2021 Meta ULC. All rights reserved