Rate and accuracy of bacterial protein synthesis revisited.

Current Opinion in Microbiology
Magnus JohanssonMåns Ehrenberg

Abstract

Our understanding of the accuracy of tRNA selection on the messenger RNA programmed ribosome has recently increased dramatically because of high-resolution crystal structures of the ribosome, cryo-electron microscopy reconstructions of its functional complexes, and fast kinetics experiments. Application of single-molecule spectroscopy with fluorescence resonance energy transfer to studies of tRNA selection by the ribosome has also provided new, albeit controversial, insights. Interestingly, when the fundamental trade-off between rate and accuracy in substrate-selective biosynthetic reactions is taken into account, some aspects of the current models of ribosome function appear strikingly suboptimal in the context of growing bacterial cells.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R C Thompson, P J Stone
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
Jan 1, 1970·Annual Review of Genetics·L Gorini
Feb 1, 1984·Quarterly Reviews of Biophysics·M Ehrenberg, C G Kurland
Sep 1, 1980·Biophysical Journal·M Ehrenberg, C Blomberg
May 16, 2000·Journal of Bacteriology·S T LiangH Bremer
May 8, 2001·Science·J M OgleV Ramakrishnan
Mar 22, 2003·RNA·Michael YarusJoachim Frank
Oct 21, 2003·Nature Structural Biology·Mikel ValleJoachim Frank
Feb 5, 2004·Molecular Cell·Kirill B Gromadski, Marina V Rodnina
Sep 28, 2004·Nature Structural & Molecular Biology·Scott C BlanchardJoseph D Puglisi
Feb 1, 2005·FEBS Letters·Marina V RodninaHans-Joachim Wieden
Jun 15, 2005·Annual Review of Biochemistry·James M Ogle, V Ramakrishnan
Feb 4, 2006·Molecular Cell·Kirill B GromadskiMarina V Rodnina
Aug 8, 2006·Biochimie·M Lovmar, M Ehrenberg
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tae-Hee LeeSteven Chu

❮ Previous
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Citations

Dec 23, 2009·Quarterly Reviews of Biophysics·Xabier Agirrezabala, Joachim Frank
Jul 30, 2010·Biochemistry·Byron HetrickSimpson Joseph
Jul 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Arvind MuruganStanislas Leibler
Jul 14, 2012·Reports on Progress in Physics·Paul C WhitfordJosé N Onuchic
Dec 12, 2012·Nucleic Acids Research·Srujana S Yadavalli, Michael Ibba
Jul 10, 2010·PLoS Computational Biology·Hao DongHuan-Xiang Zhou
Jun 12, 2013·Annual Review of Biochemistry·Rebecca M Voorhees, V Ramakrishnan
Feb 16, 2016·Nature Methods·Manuel F JuetteScott C Blanchard
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jingji ZhangMåns Ehrenberg
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Michael T EnglanderVirginia W Cornish
May 4, 2010·Journal of Molecular Biology·Peter GeggierScott C Blanchard
Dec 27, 2015·Trends in Microbiology·Thomas Ferenci
Dec 18, 2014·Biophysical Journal·Jeffrey K NoelPaul Charles Whitford
Sep 2, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Charles G Kurland
Aug 4, 2015·The Journal of Chemical Physics·Julien RacleVassily Hatzimanikatis
Apr 16, 2013·Cell·Yonatan Savir, Tsvi Tlusty
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Zorana Zeravcic, Michael P Brenner
Jun 10, 2008·Molecular Cell·Magnus JohanssonMåns Ehrenberg
Oct 31, 2014·PLoS Computational Biology·Sophia RudorfReinhard Lipowsky
May 12, 2016·Biophysical Journal·Joana Pinto VieiraVassily Hatzimanikatis
Mar 24, 2015·PloS One·Harriet Mellenius, Måns Ehrenberg
Aug 12, 2016·The Journal of Physical Chemistry. B·Kingshuk GhoshKen A Dill
Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ramu AnandakrishnanDaniel M Zuckerman
Nov 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ka-Weng IeongMåns Ehrenberg
Jan 12, 2017·Critical Reviews in Biochemistry and Molecular Biology·Michael H Schwartz, Tao Pan
Apr 5, 2017·Bulletin of Mathematical Biology·Annwesha Dutta, Debashish Chowdhury
Feb 1, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Y PavlovMåns Ehrenberg
Oct 17, 2017·Nucleic Acids Research·Harriet Mellenius, Måns Ehrenberg
Mar 23, 2017·Physical Biology·Kien Nguyen, Paul Charles Whitford
May 25, 2018·Annual Review of Biophysics·Michael Y Pavlov, Måns Ehrenberg
Dec 31, 2014·Journal of Bacteriology·Deepali AgarwalMichael O'Connor
Nov 1, 2016·Nature Communications·Jeffrey K Noel, Paul C Whitford
Jun 13, 2018·Cold Spring Harbor Perspectives in Biology·Arjun PrabhakarJoseph D Puglisi
Nov 17, 2010·Nature Reviews. Microbiology·Noah M ReynoldsMichael Ibba
Apr 24, 2015·Nature Communications·Daniel SohmenDaniel N Wilson
Jul 6, 2014·The Journal of Biological Chemistry·Benjamin J BurnettScott C Blanchard
Sep 19, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ping Xie
Sep 1, 2015·Biophysics Reviews·Paul Charles Whitford
Aug 11, 2020·The Journal of Chemical Physics·G BelA B Kolomeisky
May 5, 2017·Genetics·Peter J Vinton, Ted Weinert
Aug 17, 2018·Physical Review. E·Felix WongJeremy Gunawardena

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