Rate and predictors of success in the retreatment of chronic hepatitis C virus in HIV/hepatitis C Virus coinfected patients with prior nonresponse or relapse

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Pablo LabargaVincent Soriano

Abstract

In hepatitis C virus (HCV)/HIV-coinfected patients who failed a course of suboptimal hepatitis C therapy, retreatment with adequate doses and duration of pegylated interferon (pegIFN) plus ribavirin (RBV) is advisable in the presence of compensated advanced liver fibrosis. The efficacy and safety of pegIFN-alpha2a (180 microg/wk) plus RBV (<75 kg: 1000 mg/d; > or = 75 kg: 1200 mg/d) given for 12 months was prospectively assessed in HIV/HCV patients with nonresponse or relapse to a prior course of suboptimal hepatitis C therapy. The main endpoint was the achievement of sustained virological response (SVR). A total of 52 patients were enrolled in the study (78% HCV genotypes 1 or 4; 56% with advanced liver fibrosis). Prior suboptimal regimens were IFN monotherapy (20%), IFN plus RBV (29%), and pegIFN plus RBV 800 mg/d (51%). Overall, 61% were nonresponders and 39% relapsers. Retreatment provided SVR in 30.8% of patients (19.5% for genotypes 1/4 vs. 72.7% for genotypes 2/3; P = 0.002). In multivariate analysis, HCV genotypes 2/3 [OR 22.2, 95% confidence interval (CI), 2.9-166.7, P = 0.003] and RBV plasma trough concentrations at week 4 [OR 3.9 (95% CI, 1.3-11.8), P = 0.01] were the only independent predictors of SVR. Retreatment w...Continue Reading

References

Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouT Poynard
Mar 15, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Denise GravelGary Garber
Apr 2, 2004·Gastroenterology·Mitchell L ShiffmanUNKNOWN Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial Group
Jul 30, 2004·The New England Journal of Medicine·Francesca J TorrianiUNKNOWN APRICOT Study Group
Jul 30, 2004·The New England Journal of Medicine·Raymond T ChungUNKNOWN AIDS Clinical Trials Group A5071 Study Team
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Fabrice CarratUNKNOWN ANRS HCO2 RIBAVIC Study Team
Jan 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karin LindahlRobert Schvarcz
Dec 15, 2005·Journal of Hepatology·Miriam J Alter
Jan 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Victor de LédinghenMichel Beaugrand
Aug 16, 2006·Archives of Internal Medicine·Rainer WeberJens D Lundgren
Oct 27, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Maribel Rodríguez-TorresAcisclo M Marxuach-Cuétara
Aug 30, 2007·AIDS Research and Human Retroviruses·Marina NúñezUNKNOWN PRESCO Study Group
Dec 20, 2007·AIDS·Vincent SorianoBarbara McGovern
Sep 17, 2008·Annals of Internal Medicine·Vincent MalletStanislas Pol
Jan 7, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vincent SorianoStefan Zeuzem

❮ Previous
Next ❯

Citations

Jan 12, 2011·Current HIV/AIDS Reports·Eva A Operskalski, Andrea Kovacs
Aug 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent CotteUNKNOWN French National Agency for Research on AIDS and Viral Hepatitis (ANRS) HC26 Study Group
Nov 5, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Guillaume GeriUNKNOWN GERMIVIC Group
Jan 1, 2014·The Journal of Infection·Evguenia KrastinovaFabrice Carrat
Oct 8, 2011·Enfermedades infecciosas y microbiología clínica·Vicente SorianoPablo Barreiro
Nov 6, 2015·BMC Infectious Diseases·UNKNOWN Hepatitis C- working group for COHERE in EurocoordJürgen Rockstroh
Dec 4, 2012·Expert Review of Anti-infective Therapy·Maribel Rodríguez-Torres

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.