Rate and Temporal Coding Mechanisms in the Anterior Cingulate Cortex for Pain Anticipation

Scientific Reports
Louise UrienJing Wang

Abstract

Pain is a complex sensory and affective experience. Through its anticipation, animals can learn to avoid pain. Much is known about passive avoidance during a painful event; however, less is known about active pain avoidance. The anterior cingulate cortex (ACC) is a critical hub for affective pain processing. However, there is currently no mechanism that links ACC activities at the cellular level with behavioral anticipation or avoidance. Here we asked whether distinct populations of neurons in the ACC can encode information for pain anticipation. We used tetrodes to record from ACC neurons during a conditioning assay to train rats to avoid pain. We found that in rats that successfully avoid acute pain episodes, neurons that responded to pain shifted their firing rates to an earlier time, whereas neurons that responded to the anticipation of pain increased their firing rates prior to noxious stimulation. Furthermore, we found a selected group of neurons that shifted their firing from a pain-tuned response to an anticipatory response. Unsupervised learning analysis of ensemble spike activity indicates that temporal spiking patterns of ACC neurons can indeed predict the onset of pain avoidance. These results suggest rate and tempo...Continue Reading

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Citations

Sep 13, 2018·Journal of Computational Neuroscience·Zhengdong XiaoZhe Chen
May 21, 2019·Frontiers in Cellular Neuroscience·Zhengdong XiaoZhe Sage Chen
Dec 4, 2020·Journal of Pain Research·Michael S TrujilloJames Petros
Feb 18, 2021·Journal of Computational Neuroscience·Yuru SongZhe S Chen
Oct 4, 2020·Journal of Neuroscience Methods·Guanghao SunZhe Sage Chen

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Methods Mentioned

BETA
cognitive behavioral therapy

Software Mentioned

Open Ephys
Offline Sorter
GraphPad
MATLAB
GraphPad Prism

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