Rate and treatment of pelvic recurrence after abdominoperineal resection and low anterior resection for rectal cancer

Diseases of the Colon and Rectum
T NymannJ Christiansen

Abstract

This study was designed to analyze factors of importance for local recurrence after radical surgery for rectal cancer and to analyze course and outcome of treatment of pelvic recurrence. One hundred seventy-five patients treated for rectal cancer with low anterior resection (LAR) or abdominoperineal resection (APR) were studied, retrospectively. Seventy-four patients had LAR and 101 had APR. The two groups were comparable with respect to Dukes classification, histologic differentiation, and male to female ratio. The rate of pelvic recurrence was 18 percent for LAR and 24 percent for APR (not significant). Recurrence rates were 27 percent after stapled anastomoses and 10 percent after handsewn anastomoses respectively (P = 0.09). Twenty five had pelvic recurrence diagnosed without signs of distant metastatic disease. They were treated with radiotherapy, palliative operations, or analgesics. The group receiving radiotherapy had a significantly longer survival (15.9 months) compared with other groups (2.4 months; P < 0.001). There is no difference in local recurrence rate after LAR and APR. Radiotherapy seems to increase survival in patients with an unresectable recurrence and should be offered irrespective of pain.

References

Sep 1, 1979·The British Journal of Surgery·R J NichollsA G Parks
May 1, 1992·World Journal of Surgery·B G Wolff
May 1, 1992·World Journal of Surgery·J P de AzevedoL L Gunderson
May 1, 1987·Annals of Surgery·H J WaneboW C Constable
Feb 1, 1985·Journal of Surgical Oncology·H GraffnerB G Petersson
Dec 1, 1985·Diseases of the Colon and Rectum·W Dobrowsky, A P Schmid
Dec 1, 1982·The British Journal of Surgery·A TörnqvistL Leandoer
Feb 20, 1993·Lancet·J K MacFarlaneR J Heald
Jun 15, 1993·Cancer·D J Vaughn, D G Haller

❮ Previous
Next ❯

Citations

Sep 8, 1998·Seminars in Surgical Oncology·J N WiigO Søreide
Dec 1, 1996·Diseases of the Colon and Rectum·M HünerbeinP M Schlag
Jun 9, 2005·International Journal of Colorectal Disease·Jeffrey J MorkenCharles O Finne
May 24, 2011·International Journal of Colorectal Disease·Sigmar StelznerHelmut Witzigmann
Nov 13, 2004·Diseases of the Colon and Rectum·Jörg S KöningerKaspar Z'graggen
Jan 16, 2014·The Indian Journal of Surgery·Rakesh Kumar GuptaPanna Lal Sah
Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Farshad ForoudiWilliam J Mackillop
Feb 17, 2000·Surgical Oncology·A R Miller
Dec 12, 2001·The British Journal of Surgery·W L Law, K W Chu
Mar 30, 2010·World Journal of Surgical Oncology·Yon Kuei LimOswens S H Lo
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E Kapiteijn, C J H van de Velde
Feb 16, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·T Junginger, P Hermanek
Sep 30, 2004·The British Journal of Surgery·W L Law, K W Chu
Aug 11, 2006·Journal of Surgical Oncology·Antonio ChiappaBruno Andreoni
Jul 28, 2004·Critical Reviews in Oncology/hematology·K C M J Peeters, C J H van de Velde
Jan 1, 2003·The Surgical Clinics of North America·E Kapiteijn, C J H van de Velde
Aug 13, 2013·Journal of the Egyptian National Cancer Institute·Shapour OmidvariSaeideh Pourahmad
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iris D NagtegaalUNKNOWN Pathology Review Committee
May 11, 2018·International Journal of Colorectal Disease·Andrea BallaPierpaolo Sileri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.