Oct 1, 2011

Rate-dependent AV nodal function: closely bound conduction and refractory properties

Journal of Cardiovascular Electrophysiology
Rafik Tadros, Jacques Billette


The atrioventricular node (AV) node conducts slowly and filters atrial impulses. Puzzlingly, the recovery (conduction time vs atrial cycle length) and refractory curve (His bundle cycle length vs atrial cycle length) characterizing AV nodal function undergo disparate rate-dependent changes. We sought the functional origin and significance of these disparate changes. Differences between the recovery and refractory curve were assessed in 30 steady state AV nodal responses (all potential paired combinations between 5 basic and 6 pretest cycle lengths imposed with S(1)S(2)S(3) protocols) in rabbit heart preparations. Five of these responses corresponded to standard premature protocols. Both basic and pretest cycle length shortenings increased pretest conduction time that in turn equally shortened the ensuing His-atrial interval at all test cycle lengths. This effect was mathematically predictable and tended to shift the refractory curve downward whereas not affecting the recovery curve. Moreover, increases in pretest conduction time also shifted the recovery and refractory curve equally rightward on their x-axis, thereby biasing curve comparison between steady states. This problem could be overcome with equivalent results either by...Continue Reading

  • References15
  • Citations1


Mentioned in this Paper

Left Bundle Branch of His
Refractory Period, Electrophysiological
Right Atrial Structure
Cardiac Conduction System
Structure of Atrioventricular Node
NODAL gene
Bundle of His
Entire Atrioventricular Node
Heart Atrium

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.