PMID: 2487775Oct 1, 1989Paper

Rate of action of schistosomicides in mice infected with Schistosoma mansoni

Revista Da Sociedade Brasileira De Medicina Tropical
N KatzG C Coles

Abstract

Mice infected with adult Schistosoma mansoni were dosed with a single oral dose of 125 or 250 mg/kg oltipraz, 50 or 100 mg/kg oxamniquine, or 200 or 400 mg/kg praziquantel. The mortality rate of worms and oogram changes were determined between 1 and 16 weeks after dosing. The time required between dosing and postmortem to obtain maximum effectiveness was 1 week for praziquantel, 2 weeks for oxamniquine and 8 weeks for oltipraz. Changes in oograms persisted throughout most of the experiment, although relapse has been observed at the 4th week on.

References

Jan 1, 1985·Pharmacology & Therapeutics·P Andrews
Jul 15, 1985·Life Sciences·D CioliS Archer
Jan 1, 1968·Advances in Parasitology·J Pellegrino, N Katz
Jan 19, 1980·The Veterinary Record·M G Briscoe, G C Coles

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Citations

Apr 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Greice Krautz-PetersonPatrick J Skelly
Mar 11, 2010·Tropical Medicine & International Health : TM & IH·A GuidiH Juma Haji
Aug 20, 2010·Memórias do Instituto Oswaldo Cruz·Omar S CarvalhoMartin J Enk

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