Rate of atherosclerotic plaque formation predicts cardiovascular events in ESRD

Journal of the American Society of Nephrology : JASN
Francesco Antonio BenedettoCarmine Zoccali

Abstract

Carotid intima media thickness (IMT) is a strong, independent predictor of cardiovascular events in both the general population and among those with end-stage renal disease (ESRD), but it is unknown whether changes in IMT or other ultrasound-measured indicators of atherosclerosis over time provide additional prognostic information. The progression of atherosclerosis with carotid ultrasound was followed in a cohort of 135 ESRD patients, 103 of whom had a repeat ultrasound after 15 mo of follow-up. The number of plaques and the proportion of patients with severe atherosclerosis increased substantially during the follow-up period, but IMT, common carotid artery diameter, common carotid artery wall-to-lumen ratio, and cross-sectional area, did not change. The rate of formation of new plaques was a strong, independent predictor of incident cardiovascular events, even after adjusting for baseline plaque burden and other potential confounders. New plaque formation over time was independently predicted by background plaque burden and serum C-reactive protein (P = 0.004 and P = 0.02, respectively). Changes in IMT and the other ultrasound-measured indicators of atherosclerosis progression did not predict cardiovascular outcomes. Therefor...Continue Reading

References

May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Jul 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M L ArmstrongD J Piegors
Nov 1, 1994·Journal of Internal Medicine·G L Berglund
Feb 21, 1998·Annals of Internal Medicine·H N HodisS P Azen
May 11, 1999·Circulation·J BlacherG M London
Sep 12, 2000·Current Hypertension Reports·G B Mancini
Aug 14, 2001·Journal of the American College of Cardiology·P SchoenhagenE M Tuzcu
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Francesco Antonio BenedettoCarmine Zoccali
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliLorenzo Salvatore Malatino
Dec 17, 2002·Statistics in Medicine·Gareth AmblerPatrick Royston
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine R TuttleConnie L Davis
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshiki NishizawaMasaaki Inaba
Dec 20, 2003·Journal of the American Society of Nephrology : JASN·Giovanna LeonciniRoberto Pontremoli
Feb 16, 2005·Archives of Internal Medicine·Angela Yee-Moon WangJohn E Sanderson
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliFrancesca Mallamaci
Feb 6, 2007·European Heart Journal·Michiel L BotsDiederick E Grobbee
May 15, 2007·Journal of the American Society of Nephrology : JASN·Cheuk-Chun SzetoPhilip Kam-Tao Li

❮ Previous
Next ❯

Citations

Aug 25, 2011·Nature Reviews. Nephrology·Cristina KarohlPaolo Raggi
Sep 4, 2008·Seminars in Dialysis·Manish P Ponda, Irina Barash
Dec 17, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Marta GraciaUNKNOWN NEFRONA Investigators
Dec 1, 2010·Kidney International·Carmine Zoccali, Sidy Seck
May 11, 2010·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Guang-Wen LiXu-Dong Sun
Feb 9, 2012·Basic & Clinical Pharmacology & Toxicology·Bernardo P MarsonJose E Tanus-Santos
Jul 19, 2011·Journal of Vascular Surgery·Jaroslav PelisekHelga Frank
Feb 9, 2017·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Kerstin BenzKerstin Amann
Aug 15, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Marja van DijkJan Stephan F Sanders
Mar 10, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Milica BozicUNKNOWN NEFRONA investigators
Dec 30, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Mahmut Ilker YilmazCarmine Zoccali
Aug 16, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·José M ValdivielsoAlberto Ortiz
Jun 13, 2015·PloS One·Domingo HernándezArmando Torres
Mar 1, 2020·European Journal of Clinical Investigation·Lena TschidererPeter Willeit
Dec 5, 2019·Kidney & Blood Pressure Research·Domingo HernándezMiguel Gonzalez-Molina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.