Rate of collagen deposition during healing and ventricular remodeling after myocardial infarction in rat and dog models

Circulation
B I JugduttM I Khan

Abstract

We hypothesized that the rate and amount of infarct collagen deposition during healing after myocardial infarction might influence ventricular remodeling in rat and dog models. The purpose of this study was to compare rates of infarct collagen deposition and ventricular remodeling in the two models. Infarcted rat and dog hearts were removed at fixed time intervals between 1 and 50 days for measuring remodeling parameters and infarct and noninfarct collagen content (mg/g hydroxyproline). Collagen was less in sham rat (n=29) than dog (n=30) ventricles (3.32 versus 4.57 mg/g, P<.001) and markedly lower in the rat (n=48) than dog (n=59) infarcts throughout healing and by 50 days (9.98 versus 56.74 mg/g, P<.0001). Infarct collagen leveled off earlier and healing (histology) was completed sooner in the rat. Infarct scars were also thinner in the rat, with more (P<.0001) thinning and bulging (mm/g), and greater increase in ventricular volume. Although the mass to volume ratio decreased (P<.001) in both models, global remodeling was different, with greater transverse axis widening and globularity in the dog. Although infarct size, transmurality, heart rate, filling pressure, and blood pressure were greater in the rat, infarcts 10% to 3...Continue Reading

References

Sep 1, 1977·The American Journal of Cardiology·R J BatesC E Anagnostopoulos
Jun 1, 1978·Chest·M C FishbeinP R Maroko
Sep 1, 1992·Journal of the American College of Cardiology·B I JugduttC A Basualdo
Nov 18, 1991·The American Journal of Cardiology·P AnversaJ M Capasso
Oct 1, 1990·Journal of Molecular and Cellular Cardiology·J E BishopG J Laurent
Jun 1, 1989·Journal of the American College of Cardiology·K T Weber
Feb 1, 1985·Japanese Circulation Journal·S SekitaK Takeda
Mar 1, 1987·Canadian Journal of Physiology and Pharmacology·B I Jugdutt
Jan 1, 1986·Journal of the American College of Cardiology·B I Jugdutt, R W Amy
Nov 1, 1974·The American Journal of Cardiology·K L GouldJ W Kennedy
Mar 1, 1983·The American Journal of Cardiology·C S RobertsR A Kloner
Jul 1, 1982·The American Journal of Cardiology·J S Hochman, B H Bulkley
Sep 8, 1993·Molecular and Cellular Biochemistry·S C TyagiK T Weber
Jul 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·C J MARTIN, A E AXELROD
Jan 1, 1936·Transactions of the American Clinical and Climatological Association·P D WhiteJ Salcedo-Salgar

❮ Previous
Next ❯

Citations

Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Nobuhisa OhnoRen-Ke Li
Jan 8, 1999·International Journal of Cardiology·A KawamotoK Dohi
Jul 18, 2000·Journal of the American College of Cardiology·S WeiJ E Sanderson
May 3, 2002·Journal of the American College of Cardiology·Bodh I JugduttHalliday Idikio
Jan 20, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bridget Louise LeonardIan John LeGrice
Apr 26, 2012·Nature Communications·Murat Guvendiren, Jason A Burdick
Nov 13, 1998·Current Opinion in Lipidology
Oct 16, 2009·Cardiology in Review·David C SaneRichard C Becker
Oct 24, 1998·Journal of Cardiovascular Electrophysiology·A Burashnikov, C Antzelevitch
Jun 18, 2002·Journal of Interventional Cardiology·David E Kandzari, Kenneth W Mahaffey
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Santosh K SanganalmathNaranjan S Dhalla
Feb 15, 2011·Annual Review of Physiology·Jennifer A Dixon, Francis G Spinale
Jun 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Krystyna M ShiouraPaul H Goldspink
Oct 26, 2010·Circulation. Heart Failure·Karl D PendergrassMichael E Davis
Dec 5, 2009·Circulation Research·Colby A SoudersTroy A Baudino
Feb 16, 2013·Journal of Translational Medicine·Yue-Feng ChenAnthony Martin Gerdes
Aug 7, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Usha SubramanianStephen Sawada
Feb 25, 2010·Journal of Cardiovascular Medicine·Eduard SleepJuan Carlos Izpisua Belmonte
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jennifer A Dixon, Francis G Spinale
Jan 28, 2014·Stem Cell Research & Therapy·Kelly Elizabeth SullivanLauren Deems Black
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·J M LeferovichE Heber-Katz
Sep 27, 2002·Seminars in Cell & Developmental Biology·John M Leferovich, Ellen Heber-Katz
Jul 1, 2011·Heart Failure Reviews·Linn MooreZamaneh Kassiri
Jan 17, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hendra WahyudiS Michael Yu
Jan 21, 2012·Pharmacology & Therapeutics·Xiao-Ming GaoXiao-Jun Du
May 25, 2010·International Journal of Cardiology·Cord ManhenkeKenneth Dickstein
May 5, 2007·Cardiology Clinics·Jonathan W WeinsaftRobert M Judd
Sep 24, 2015·Journal of Cardiovascular Translational Research·William J Richardson, Jeffrey W Holmes
Feb 5, 2009·Contrast Media & Molecular Imaging·H M H F SandersK Nicolay
Sep 26, 2007·Angewandte Chemie·Peter CaravanZhaoda Zhang
Feb 26, 2013·Biopolymers·Wael R Abd-Elgaliel, Ching-Hsuan Tung
Apr 13, 2011·Microscopy Research and Technique·Hildebrando G BenedictoIsaura M M Prado

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.