PMID: 9420309Jan 7, 1998Paper

Rate of decline of percentage CD4+ cells is faster in HIV-1 than in HIV-2 infection

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
S JaffarH C Whittle

Abstract

Increasing evidence suggests that the pathogenesis of HIV-1 is different from that of HIV-2. Thus, we have measured, longitudinally at various times over a median follow-up of 2.1 years, the percentage CD4+ cells of 94 patients infected with HIV-1 and 164 patients infected with HIV-2. The pattern of decline of CD4% over time was linear for patients with either infection. Multilevel statistical modeling techniques showed that after stratifying for HIV status, the rate of decline of CD4% was faster among patients who died than among those who survived (difference in rate of decline = 2.34% CD4+ cells/year; p = 0.0002). After stratifying for survival status, the rate of decline was faster and less variable among patients infected with HIV-1 than among patients infected with HIV-2 (difference in rate of decline = 1.12% CD4+ cells/year; p = 0.05). The proportion of patients who showed no fall in CD4+ cells was higher in HIV-2 than in HIV-1 infection (p = 0.026). These data suggest fundamental differences between the two infections, with HIV-1 being more pathogenic resulting in a faster and more homogeneous rate of decline than HIV-2. In HIV-2 infection, disease in many patients progresses slowly, but in some the advance is just as f...Continue Reading

References

Feb 16, 1991·Lancet·A N PhillipsP B Kernoff
Dec 1, 1991·AIDS·A WilkinsM Rolfe
Mar 1, 1995·International Journal of STD & AIDS·M Miyazaki
Apr 16, 1994·Lancet·P J KankiJ L Sankalé
Nov 3, 1993·JAMA : the Journal of the American Medical Association·K M De CockH D Gayle
Jan 1, 1993·Bulletin of Mathematical Biology·C DonnellyS Sandberg
Dec 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·I M LisseF Dias

❮ Previous
Next ❯

Citations

Sep 29, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Katie HarriesAnthony Harries
Sep 2, 1998·Current Opinion in Immunology·H C WhittleS Rowland-Jones
Apr 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antoine BenardUNKNOWN ACHIEV2E Collaboration Study Group
Jun 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hetty BlaakAlbert D M E Osterhaus
May 15, 2013·AIDS·Dana N RaugiUNKNOWN University of Washington-Dakar HIV Study Group
Oct 22, 2010·HIV Medicine·Y GilleeceUNKNOWN BHIVA Guidelines Subcommittee
Jun 25, 2004·Retrovirology·Barbara AhrMartine Biard-Piechaczyk
May 21, 2010·Retrovirology·Maarten F Schim van der LoeffHilton Whittle
Feb 10, 2009·Virus Research·Q Santos-CostaJ M Azevedo-Pereira
Mar 4, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Russell B FoxallAna E Sousa
May 18, 2004·Infectious Disease Clinics of North America·Cristian ApetreiStephen M Smith
Mar 6, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Annabelle J GourlayMaarten F Schim van der Loeff
Feb 13, 2003·Experimental Gerontology·Kevork HagopianRichard Weindruch
Aug 27, 2014·BMC Infectious Diseases·Didier K EkoueviSerge P Eholie
May 12, 2004·Journal of Theoretical Biology·Ursula Mittwoch
Sep 8, 2009·Journal of Human Evolution·Karin Isler, Carel P van Schaik
Nov 15, 2007·European Journal of Immunology·Rita CavaleiroAna E Sousa
Sep 2, 1999·Tropical Medicine & International Health : TM & IH·S JaffarH Whittle
Sep 15, 2004·Acta Microbiologica Et Immunologica Hungarica·Dalma Vödrös, Eva Mária Fenyö
Mar 27, 2009·AIDS Research and Human Retroviruses·Rita CavaleiroAna E Sousa
Jul 18, 2018·Antimicrobial Agents and Chemotherapy·Robert A SmithUNKNOWN University of Washington-Dakar HIV-2 Study Group
Nov 27, 2015·Journal of Virology·Yunji W DavenportPamela J Bjorkman
Apr 9, 2008·Expert Review of Vaccines·Aleksandra Leligdowicz, Sarah Rowland-Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.