Rate of Gestational Diabetes Mellitus and Pregnancy Outcomes in Patients with Chronic Hypertension

American Journal of Perinatology
Mateo G LeonBaha M Sibai

Abstract

Objective This study aims to determine the rate of gestational diabetes mellitus (GDM) in pregnancies complicated by chronic hypertension and to compare the adverse outcomes in chronic hypertensive pregnancies with and without GDM. Study Design A secondary analysis from a multicenter trial of low-dose aspirin for preeclampsia prevention in women with chronic hypertension. The rate of GDM was evaluated among singleton pregnancies complicated with chronic hypertension and grouped according to their GDM status. Pregnancy outcomes and rates of preterm delivery < 35 weeks and < 32 weeks, preeclampsia, indicated preterm birth, small for gestational age, abruptio placentae, and perinatal death were compared between those with and without GDM. A subgroup analysis comparing women who developed superimposed preeclampsia with and without GDM was studied. Multivariate logistic-regression analysis was used to adjust for potentially confounding factors. Results A total of 763 women met the inclusion criteria: 129 (17%) developed GDM. Parity, race, maternal baseline blood pressure, antihypertensive drug use, and assignment to low-dose aspirin were not significantly different between the groups with and without GDM. Using univariate analysis, ...Continue Reading

Citations

Dec 23, 2016·Clinical Obstetrics and Gynecology·Nana-Ama E Ankumah, Baha M Sibai
Jan 3, 2018·International Journal of Environmental Research and Public Health·Xianglong XuYong Zhao
Jan 26, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maeve E WallaceEmily Harville
Aug 11, 2018·Obstetrics and Gynecology·Maya RamUNKNOWN Diabetes, Obesity and Hypertension in Pregnancy Research Network (DOH-NET) and the Southern Ontario Obstetrical Network (SOO
May 24, 2017·Hypertension·Maria HoeltzenbeinChristof Schaefer
Dec 24, 2018·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Lelia DuleyLisa M Askie
Mar 23, 2020·American Journal of Obstetrics and Gynecology·Ioannis BellosGeorgios Daskalakis
Nov 13, 2019·American Journal of Obstetrics and Gynecology·Ashley N BattarbeeAlan T N Tita
Aug 17, 2021·Journal of Neonatal-perinatal Medicine·L CorderoC A Nankervis

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