Rate of Kidney Function Decline and Risk of Hospitalizations in Stage 3A CKD

Clinical Journal of the American Society of Nephrology : CJASN
Yan XieZiyad Al-Aly

Abstract

Risk of hospitalizations is increased in patients with CKD. We sought to examine the association between rate of kidney function decline and risk of hospitalization in a cohort of patients with early CKD. We built a cohort of 247,888 United States veterans who had at least one eGFR measurement between October 1999 and September 2003 and an additional eGFR between October 2003 and September 2004. We selected patients whose initial eGFR was between 45 and 59 ml/min per 1.73 m2. Rate of eGFR change (in milliliters per minute per 1.73 m2 per year) was categorized as no decline (>0), mild (0 to -1, and served as the referent group), moderate (-1 to -5), or severe (>-5) eGFR decline. We built survival models to examine the association between the rate of kidney function decline and the risk of hospitalization and readmission and linear regression to estimate length of hospital stay. Over a median observation of 9 years (interquartile range, 5.28-9.00), patients with moderate and severe eGFR decline exhibited a higher risk of hospitalizations (hazard ratio [HR], 1.22; 95% confidence interval [95% CI], 1.19 to 1.26; and HR, 1.33; 95% CI, 1.28 to 1.39, respectively). Among patients with moderate and severe eGFR decline, the association ...Continue Reading

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Citations

Mar 8, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yan XieZiyad Al-Aly
Apr 16, 2016·Journal of the American Society of Nephrology : JASN·Yan XieZiyad Al-Aly
Aug 16, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Benjamin BoweZiyad Al-Aly
Jan 27, 2017·Journal of Atherosclerosis and Thrombosis·Kaori HayashiHiroshi Itoh
Sep 1, 2017·Canadian Journal of Kidney Health and Disease·William F ClarkJessica M Sontrop
Jul 6, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Yan XieZiyad Al-Aly
Oct 20, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Esteban A Cedillo-CouvertUNKNOWN CRIC Study Investigators
Sep 25, 2017·Journal of the American Society of Nephrology : JASN·Benjamin BoweZiyad Al-Aly
Mar 30, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Benjamin BoweZiyad Al-Aly
Feb 6, 2017·PloS One·Tingting LiZiyad Al-Aly
Dec 8, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Aslam AmodUNKNOWN DEVOTE Study Group
Dec 12, 2020·PLoS Medicine·Sarah J SchraubenUNKNOWN CRIC Study Investigators
Nov 18, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Benjamin BoweZiyad Al-Aly
Jun 26, 2021·KI Reports·Anand SrivastavaUNKNOWN CRIC Study Investigators
Jul 11, 2021·The International Journal of Pharmacy Practice·Alexander SchützePeter Benöhr
Apr 22, 2020·Cardiorenal Medicine·Jefferson Lorenzo TriozziSankar D Navaneethan

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