PMID: 1535031Apr 24, 1992Paper

Rate of recovery of D1 and D2 dopaminergic receptors in young vs. adult rat striatal tissue following alkylation with ethoxycarbonyl-ethoxy-dihydroquinoline (EEDQ)

Brain Research. Developmental Brain Research
N S KulaR J Baldessarini


The rate of recovery of D1 and D2 receptor binding sites in rat striatal tissue labeled with [3H]SCH-23390 or [3H]YM-09151-2 was followed daily after irreversible blockade of these receptors with the alkylating agent ethoxycarbonyl-ethoxy-dihydroquinoline (EEDQ). These rates were significantly higher in young post-weaning rats than in young adults (14% vs. 7% per day). The findings suggest that rates of synthesis of new D1 and D2 receptor proteins may be increased during a phase of neurodevelopment in the first postnatal month when the accumulation of both receptor types, especially of D1 receptors, is about maximal.


Mar 1, 1992·Neurochemistry International·J L NeumeyerR J Baldessarini
Sep 1, 1989·Brain Research. Developmental Brain Research·H A GelbardR J Baldessarini
Dec 1, 1987·European Journal of Pharmacology·K R JarvieP Seeman
Mar 1, 1988·Journal of Neurochemistry·W Y ZengL C Murrin
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S E LeffI Creese

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Aug 19, 2003·European Journal of Pharmacology·John L NeumeyerRoss J Baldessarini
Dec 29, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Y Turner, M R Soliman
Aug 30, 2000·Neuropharmacology·F I TaraziR J Baldessarini
Mar 22, 1996·Annals of the New York Academy of Sciences·S J Cooper

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